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• W2188211408 abstract "SUMMARY Synthesis of cholesterol and fatty acids was measured in vitro in the livers of rats from which the bile had been drained for various periods of time, and in control rats with normal enterohepatic circulation. Cholic and chenodeoxycholic acids were excreted at an initial rate of more than 5 mg per hour. The rate fell rapidly to a minimum, followed by a secondary rise beginning between the twentieth and thirtieth hour after cannulation. After draining the bile for 12 hours or longer, there was an increase in the synthesis of cholesterol from acetate, but not from mevalonate, and a slight depression of fatty acid synthesis. Liver cholesterol content was unchanged. Although these data suggest that the increased production of bile acids may be secondary to an increase in cholesterol synthesis, other explanations cannot be excluded. When the common bile duct of a rat is drained continuously, the rate of excretion of bile acids decreases during the first day (l) and then increases (a), reaching a plateau by about the third day after cannulation. Thompson and Vars (2) assumed that the early fall in the rat.e of excretion was due to temporary damage to the liver caused by the operation, and that the plateau value indicated the normal rate of bile acid formation in the intact animal. Eriksson (3), however, has put forward evidence that t,he normal rate is represented by the minimum value observed toward the end of the first day, and that the plateau value represents an abnormally high rate of formation, brought about by the continual removal of bile acids through the cannula. All the bile acids are derived from cholesterol. Moreover, oxidation to bile acids is the most important pathway for the elimination of cholesterol in rats (4). A marked increase in bile-acid formation, such as that supposed by Eriksson to occur after cannulation of the bile duct, should therefore be accompanied by an increase in the synthesis of cholesterol, provided that there is no corresponding decrease in the cholesterol c*ontaent of the liver." @default.
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• W2188211408 date "1961-10-01" @default.
• W2188211408 modified "2023-10-14" @default.
• W2188211408 title "The effect of biliary drainage upon the synthesis of cholesterol in the liver" @default.
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• W2188211408 doi "https://doi.org/10.1016/s0022-2275(20)40480-8" @default.
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