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- W2188222113 abstract "We studied thepressuredeveloped bythediaphragm inresponse tostimulation of thephrenic nerveintheneck, inthree normal men. Whenthephrenic was electrically stimulated atincreasing frequencies thediaphragm responded byincreasing transdiaphragmatic pressure to give a frequency-pressure curvesimilar to,thefrequency-force curveforother skeletal muscles. Thesubjects thenbreathed through an ispiratory resistance foraslong aspossible andthe frequency-pressure curve was repeated. Itl was foundthatthediaphragm developed lowfre- quencyfatigue, inthesame way aspreviously described forother muscles. We conclude thatthe diaphragm hascontractile properties similar tothose ofother skeletal muscles. Lowfrequency fatigue ofthediaphragm could contribute torespiratory failure inpatients withlungdisease. Thediaphragm isthemostimportant muscle of respiration. Therehavebeenfewstudies ofthe contractile properties ofthis muscle although the response toelectrical stimulation hasbeenstudied inanimals,' andthehumandiaphragm hasbeen investigated invitro.2 3Thesestudies suggested thatthe contractile characteristics of the diaphragm weresimilar tothose ofother skeletal muscles. However, there hasbeennoinvivostudy inman.Techniques arenowwellestablished for measuring theforce ofisometric contraction ofa large proximal muscle(quadriceps) anda small distal muscle(adductor pollicis) after electrical stimulation at different frequencies-the fre- quency-force curve.4 Thesametechnique has" @default.
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- W2188222113 date "1981-01-01" @default.
- W2188222113 modified "2023-09-27" @default.
- W2188222113 title "Contractile properties andfatigue ofthe diaphragm inman" @default.
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