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- W2188235004 abstract "One of the anti-diabetic therapeutic strategies is inhibition of carbohydrate digesting enzymes such as alpha-amylase and alphaglucosidase. In the present study, 2 extracts namely, aqueous and ethanol of Ocimum sanctum Linn. were evaluated for their effect on alpha-amylase and alpha-glucosidase enzymes using in vitro assays. Aqueous extract showed the highest alpha-glucosidase inhibitory activity (IC50= 26.75 µg/ml) than ethanol extract. However, both the extracts inhibited the enzyme more potently than the standard acarbose. Further, the antioxidant activity of extracts was monitored using DPPH assay, whereas, phenolic content was estimated using Folin-Ciocalteu reagent. The alpha-glucosidase inhibitory activity of O. sanctum correlated to antioxidant activity and phenolic content of extracts. However, these extracts showed no alpha-amylase inhibitory activity. Besides, O. sanctum has shown anti-HIV potential in our previous study. Oxidative stress and anti-HIV drugs are associated with diabetes. Our current and previous studies thus report anti-diabetic, antioxidant and anti-HIV activities of O. sanctum." @default.
- W2188235004 created "2016-06-24" @default.
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- W2188235004 date "2014-01-01" @default.
- W2188235004 modified "2023-09-27" @default.
- W2188235004 title "Evaluation of Alpha-Amylase and Alpha-Glucosidase Inhibitory Activities of Ocimum sanctum Linn" @default.
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