FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188255977> ?p ?o ?g. }

• W2188255977 endingPage "6726" @default.
• W2188255977 startingPage "6719" @default.
• W2188255977 abstract "Gram-negative bacteria (GNB) are a leading cause of nosocomial infection and sepsis. Increasing multi-antibiotic resistance has left clinicians with fewer therapeutic options. Antibodies to GNB lipopolysaccharide (LPS, or endotoxin) have reduced morbidity and mortality as a result of infection and are not subject to the resistance mechanisms deployed by bacteria against antibiotics. In this phase 1 study, we administered a vaccine that elicits antibodies against a highly conserved portion of LPS with and without a CpG oligodeoxynucleotide (ODN) TLR9 agonist as adjuvant.A vaccine composed of the detoxified LPS (dLPS) from E. coli O111:B4 (J5 mutant) non-covalently complexed to group B meningococcal outer membrane protein (OMP). Twenty healthy adult subjects received three doses at 0, 29 and 59 days of antigen (10 μg dLPS) with or without CPG 7909 (250 or 500 μg). Subjects were evaluated for local and systemic adverse effects and laboratory findings. Anti-J5 LPS IgG and IgM antibody levels were measured by electrochemiluminesence. Due to premature study termination, not all subjects received all three doses.All vaccine formulations were well-tolerated with no local or systemic events of greater than moderate severity. The vaccine alone group achieved a ≥ 4-fold responder response in IgG and IgM antibody in only one of 6 subjects. In contrast, the vaccine plus CPG 7909 groups appeared to have earlier and more sustained (to 180 days) responses, greater mean-fold increases, and a higher proportion of responders achieving ≥ 4-fold increases over baseline.Although the study was halted before all enrolled subjects received all three doses, the J5dLPS/OMP vaccine, with or without CpG adjuvant, was safe and well-tolerated. The inclusion of CpG increased the number of subjects with a ≥ 4-fold antibody response, evident even after the second of three planned doses. A vaccine comprising J5dLPS/OMP antigen with CpG adjuvant merits further investigation.ClinicalTrials.gov Identifier: NCT01164514." @default.
• W2188255977 created "2016-06-24" @default.
• W2188255977 creator A5003385022 @default.
• W2188255977 creator A5016637485 @default.
• W2188255977 creator A5018227896 @default.
• W2188255977 creator A5030558280 @default.
• W2188255977 creator A5035368548 @default.
• W2188255977 creator A5071573513 @default.
• W2188255977 creator A5089572687 @default.
• W2188255977 date "2015-11-01" @default.
• W2188255977 modified "2023-09-27" @default.
• W2188255977 title "Phase 1 testing of detoxified LPS/group B meningococcal outer membrane protein vaccine with and without synthetic CPG 7909 adjuvant for the prevention and treatment of sepsis" @default.
• W2188255977 cites W1845158209 @default.
• W2188255977 cites W1891797115 @default.
• W2188255977 cites W1952804450 @default.
• W2188255977 cites W1973347267 @default.
• W2188255977 cites W1975055022 @default.
• W2188255977 cites W1991379729 @default.
• W2188255977 cites W1996033260 @default.
• W2188255977 cites W2007283811 @default.
• W2188255977 cites W2036187664 @default.
• W2188255977 cites W2037241970 @default.
• W2188255977 cites W2042565293 @default.
• W2188255977 cites W2043697982 @default.
• W2188255977 cites W2048163712 @default.
• W2188255977 cites W2048259076 @default.
• W2188255977 cites W2059908643 @default.
• W2188255977 cites W2073054640 @default.
• W2188255977 cites W2074503728 @default.
• W2188255977 cites W2075892592 @default.
• W2188255977 cites W2085357859 @default.
• W2188255977 cites W2089621550 @default.
• W2188255977 cites W2092193084 @default.
• W2188255977 cites W2092632695 @default.
• W2188255977 cites W2092643722 @default.
• W2188255977 cites W2098572294 @default.
• W2188255977 cites W2100806538 @default.
• W2188255977 cites W2113898837 @default.
• W2188255977 cites W2122280164 @default.
• W2188255977 cites W2124290234 @default.
• W2188255977 cites W2128728367 @default.
• W2188255977 cites W2130070772 @default.
• W2188255977 cites W2132100196 @default.
• W2188255977 cites W2137059754 @default.
• W2188255977 cites W2138763270 @default.
• W2188255977 cites W2143053879 @default.
• W2188255977 cites W2144523774 @default.
• W2188255977 cites W2145877152 @default.
• W2188255977 cites W2148356388 @default.
• W2188255977 cites W2149213889 @default.
• W2188255977 cites W2160577642 @default.
• W2188255977 cites W2165748707 @default.
• W2188255977 cites W2168045627 @default.
• W2188255977 cites W2325286363 @default.
• W2188255977 cites W2328804315 @default.
• W2188255977 cites W2410322037 @default.
• W2188255977 cites W4232565521 @default.
• W2188255977 cites W4385795638 @default.
• W2188255977 doi "https://doi.org/10.1016/j.vaccine.2015.10.072" @default.
• W2188255977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4679452" @default.
• W2188255977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26514420" @default.
• W2188255977 hasPublicationYear "2015" @default.
• W2188255977 type Work @default.
• W2188255977 sameAs 2188255977 @default.
• W2188255977 citedByCount "9" @default.
• W2188255977 countsByYear W21882559772018 @default.
• W2188255977 countsByYear W21882559772019 @default.
• W2188255977 countsByYear W21882559772020 @default.
• W2188255977 countsByYear W21882559772021 @default.
• W2188255977 countsByYear W21882559772023 @default.
• W2188255977 crossrefType "journal-article" @default.
• W2188255977 hasAuthorship W2188255977A5003385022 @default.
• W2188255977 hasAuthorship W2188255977A5016637485 @default.
• W2188255977 hasAuthorship W2188255977A5018227896 @default.
• W2188255977 hasAuthorship W2188255977A5030558280 @default.
• W2188255977 hasAuthorship W2188255977A5035368548 @default.
• W2188255977 hasAuthorship W2188255977A5071573513 @default.
• W2188255977 hasAuthorship W2188255977A5089572687 @default.
• W2188255977 hasBestOaLocation W21882559772 @default.
• W2188255977 hasConcept C104317684 @default.
• W2188255977 hasConcept C126322002 @default.
• W2188255977 hasConcept C150194340 @default.
• W2188255977 hasConcept C159654299 @default.
• W2188255977 hasConcept C190727270 @default.
• W2188255977 hasConcept C197934379 @default.
• W2188255977 hasConcept C203014093 @default.
• W2188255977 hasConcept C22801619 @default.
• W2188255977 hasConcept C2777863537 @default.
• W2188255977 hasConcept C2778384902 @default.
• W2188255977 hasConcept C2778458888 @default.
• W2188255977 hasConcept C2778754761 @default.
• W2188255977 hasConcept C2779138994 @default.
• W2188255977 hasConcept C2780454893 @default.
• W2188255977 hasConcept C2780801004 @default.
• W2188255977 hasConcept C501593827 @default.
• W2188255977 hasConcept C523546767 @default.
• W2188255977 hasConcept C54355233 @default.
• W2188255977 hasConcept C55493867 @default.

• next