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- W2188280848 abstract "ABSTRACT The C3d receptor (CR2) of human B lym-phocytes mediates the binding to these cells ofimmunecom-plexesthathaveactivated thecomplementsystemandbearthefragments of C3, iC3b, C3d,g, andC3d. A 145,000 Mrmem-brane protein previously described as beingrecognized by themonoclonalantibodyHB-5andshownto beexpressedonlybyB lymphocytes andB lymphoblastoid cell lines, such as Raji,wasassessedforits possibleidentityasCR2.TreatmentofRajicells withHB-5andgoat F(ab')2 anti-mouse IgG(GaM)dimin- ished the capacity of these cells to form rosettes with sheep erythrocyte (E) intermediates bearing 130,000 molecules ofiC3borC3d,whereastreatmentwiththemonoclonalantibodyalone had noeffect. The capacity of peripheral blood B lym- phocytestobindEC3dwassimilarlyinhibited by thecombina-tionofHB-5andGaM.The possibility thatHB-5mayinteractwith asite onCR2that is distinct fromtheligand bindingsitepermitted the direct analysis ofthe capacity oftheHB-5anti-gento bindto theC3 fragments. Protein A-containingStaphy-lococcus" @default.
- W2188280848 created "2016-06-24" @default.
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- W2188280848 date "1984-01-01" @default.
- W2188280848 modified "2023-09-27" @default.
- W2188280848 title "Identification ofa145,000 Mrmembraneprotein astheC3dreceptor (CR2)ofhumanB Iymphocytes (complement/Raji cells/monoclonal antibodies)" @default.
- W2188280848 hasPublicationYear "1984" @default.
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