FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188294113> ?p ?o ?g. }

• W2188294113 endingPage "L283" @default.
• W2188294113 startingPage "L276" @default.
• W2188294113 abstract "Nitric oxide (NO) is thought to play an important role in the regulation of neonatal pulmonary vasculature. It has been suggested that neonates with pulmonary hypertension have a defective NO pathway. Therefore, we measured in 1-day-old piglets exposed to hypoxia (fraction of inspired O(2) = 0.10) for 3 or 14 days to induce pulmonary hypertension 1) the activity of NO synthase (NOS) via conversion of L-arginine to L-citrulline and the concentration of the NO precursor L-arginine in isolated pulmonary vessels, 2) the vasodilator response to the NO donor 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1) and the cGMP analog 8-bromo-cGMP in isolated perfused lungs, and 3) the production of cGMP in response to SIN-1 in isolated perfused lungs. After 3 days of exposure to hypoxia, endothelial NOS (eNOS) activity was unaffected, whereas, after 14 days of hypoxia, eNOS activity was decreased in the cytosolic fraction of pulmonary artery (P < 0.05) but not of pulmonary vein homogenates. Inducible NOS activity was decreased in the cytosolic fraction of pulmonary artery homogenates after both 3 (P < 0.05) and 14 (P < 0.05) days of hypoxia but was unchanged in pulmonary veins. Pulmonary artery levels of L-arginine were unaffected by hypoxic exposure. After 3 days of exposure to hypoxia, the reduction in the dilator response to SIN-1 (P < 0.05) coincided with a decrease in cGMP production (P < 0.005), suggesting that soluble guanylate cyclase activity may be altered. When the exposure was prolonged to 14 days, dilation to SIN-1 remained decreased (P < 0.05) and, although cGMP production normalized, the dilator response to 8-bromo-cGMP decreased (P < 0.05), suggesting that, after prolonged exposure to hypoxia, cGMP-dependent mechanisms may also be impaired. In conclusion, neonatal hypoxia-induced pulmonary hypertension is associated with multiple disruptions in the NO pathway." @default.
• W2188294113 created "2016-06-24" @default.
• W2188294113 creator A5024534078 @default.
• W2188294113 creator A5066903097 @default.
• W2188294113 creator A5087677353 @default.
• W2188294113 date "2000-02-01" @default.
• W2188294113 modified "2023-10-15" @default.
• W2188294113 title "Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension" @default.
• W2188294113 cites W119779276 @default.
• W2188294113 cites W126084796 @default.
• W2188294113 cites W1596787745 @default.
• W2188294113 cites W1873666566 @default.
• W2188294113 cites W1883906051 @default.
• W2188294113 cites W1966627446 @default.
• W2188294113 cites W1993387193 @default.
• W2188294113 cites W1997284319 @default.
• W2188294113 cites W2004464965 @default.
• W2188294113 cites W2023690476 @default.
• W2188294113 cites W2042782418 @default.
• W2188294113 cites W2043583232 @default.
• W2188294113 cites W2048635427 @default.
• W2188294113 cites W2051031104 @default.
• W2188294113 cites W2072150226 @default.
• W2188294113 cites W2092478589 @default.
• W2188294113 cites W2092947671 @default.
• W2188294113 cites W2127162829 @default.
• W2188294113 cites W2143692326 @default.
• W2188294113 cites W2156120690 @default.
• W2188294113 cites W2172818941 @default.
• W2188294113 cites W2200796344 @default.
• W2188294113 cites W2218034046 @default.
• W2188294113 cites W2264444008 @default.
• W2188294113 cites W2284232659 @default.
• W2188294113 cites W2326718956 @default.
• W2188294113 cites W2334211460 @default.
• W2188294113 cites W2395724944 @default.
• W2188294113 cites W2410629086 @default.
• W2188294113 cites W2410872023 @default.
• W2188294113 cites W2412446159 @default.
• W2188294113 cites W2418817078 @default.
• W2188294113 cites W2419010944 @default.
• W2188294113 cites W2424621093 @default.
• W2188294113 cites W2426643649 @default.
• W2188294113 cites W4293247451 @default.
• W2188294113 doi "https://doi.org/10.1152/ajplung.2000.278.2.l276" @default.
• W2188294113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10666111" @default.
• W2188294113 hasPublicationYear "2000" @default.
• W2188294113 type Work @default.
• W2188294113 sameAs 2188294113 @default.
• W2188294113 citedByCount "48" @default.
• W2188294113 countsByYear W21882941132012 @default.
• W2188294113 countsByYear W21882941132014 @default.
• W2188294113 countsByYear W21882941132015 @default.
• W2188294113 countsByYear W21882941132016 @default.
• W2188294113 countsByYear W21882941132017 @default.
• W2188294113 countsByYear W21882941132018 @default.
• W2188294113 countsByYear W21882941132020 @default.
• W2188294113 crossrefType "journal-article" @default.
• W2188294113 hasAuthorship W2188294113A5024534078 @default.
• W2188294113 hasAuthorship W2188294113A5066903097 @default.
• W2188294113 hasAuthorship W2188294113A5087677353 @default.
• W2188294113 hasConcept C120770815 @default.
• W2188294113 hasConcept C126322002 @default.
• W2188294113 hasConcept C134018914 @default.
• W2188294113 hasConcept C178790620 @default.
• W2188294113 hasConcept C185592680 @default.
• W2188294113 hasConcept C2777032099 @default.
• W2188294113 hasConcept C2777468819 @default.
• W2188294113 hasConcept C2777622882 @default.
• W2188294113 hasConcept C2777714996 @default.
• W2188294113 hasConcept C2778326061 @default.
• W2188294113 hasConcept C2779129087 @default.
• W2188294113 hasConcept C2779376020 @default.
• W2188294113 hasConcept C2780930700 @default.
• W2188294113 hasConcept C2780940725 @default.
• W2188294113 hasConcept C515207424 @default.
• W2188294113 hasConcept C519581460 @default.
• W2188294113 hasConcept C540031477 @default.
• W2188294113 hasConcept C55493867 @default.
• W2188294113 hasConcept C71924100 @default.
• W2188294113 hasConcept C7836513 @default.
• W2188294113 hasConcept C86803240 @default.
• W2188294113 hasConceptScore W2188294113C120770815 @default.
• W2188294113 hasConceptScore W2188294113C126322002 @default.
• W2188294113 hasConceptScore W2188294113C134018914 @default.
• W2188294113 hasConceptScore W2188294113C178790620 @default.
• W2188294113 hasConceptScore W2188294113C185592680 @default.
• W2188294113 hasConceptScore W2188294113C2777032099 @default.
• W2188294113 hasConceptScore W2188294113C2777468819 @default.
• W2188294113 hasConceptScore W2188294113C2777622882 @default.
• W2188294113 hasConceptScore W2188294113C2777714996 @default.
• W2188294113 hasConceptScore W2188294113C2778326061 @default.
• W2188294113 hasConceptScore W2188294113C2779129087 @default.
• W2188294113 hasConceptScore W2188294113C2779376020 @default.
• W2188294113 hasConceptScore W2188294113C2780930700 @default.
• W2188294113 hasConceptScore W2188294113C2780940725 @default.
• W2188294113 hasConceptScore W2188294113C515207424 @default.
• W2188294113 hasConceptScore W2188294113C519581460 @default.

• next