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- W2188297775 abstract "The aim of this study was to investigate the radical scavenging and immunomodulatory properties of the flavonoid isolated from Phyllanthus niruri. Antioxidant activities were evaluated using various assays such as the 1, 1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging assay and hydroxyl radical scavenging assay. In vitro assay of immunomodulatory activity of flavonoid isolated from Phyllanthus niruri was done by using lymphocytes. The isolated flavonoid exhibited a dose-dependent enhancement in activity in DPPH assay and hydroxyl radical scavenging assays. In DPPH assay the isolate exhibited strong DPPH radical scavenging activity with IC50 value of 48.98μg/ml when compared to the IC50 value of the reference standard, ascorbic acid 21.11μg/ml. In hydroxyl radical scavenging assay 100μg of quercetin equivalent activity was shown by 468.12μg of isolated flavonoid. Flavonoid isolated from Phyllanthus niruri showed in vitro growth stimulatory effect on isolated normal lymphocytes which was estimated by MTT assay. Percentages of proliferation of lymphocytes at different concentrations were obtained. The results of the present study indicate that the flavono id isolated from Phyllanthus niruri is a compound having potent antioxidant and immunomodulatory activities." @default.
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- W2188297775 date "2014-08-25" @default.
- W2188297775 modified "2023-09-26" @default.
- W2188297775 title "Study of In vitro Immunomodulatory Effect of Flavonoid Isolated from Phyllanthus niruri on Human Blood Lymphocytes and Evaluation of its Antioxidant Potential" @default.
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