FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188298034> ?p ?o ?g. }

• W2188298034 abstract "Serum and tissue markers of myopathy in patients with colorectal cancer Skeletal muscles in patients with cancer undergo many changes due to immuno-inflammatory factors of tumor origin, or to chemotherapy and irradiation. Aim of the present study is to identify serological biomarkers and early myopathic features in skeletal muscle biopsies from weight stable patients bearing colorectal cancer at the onset of disease. Morphometric analyses by histochemistry and immunohistochemistry were performed on intraoperative muscle biopsies from patients with early colorectal cancer and from weight stable patients undergoing surgery for benign non-inflammatory conditions. Serological analyses for testing markers of inflammation (C Reactive Protein, CRP), muscle enzymes, (Creatin Kinase, CK), soluble isoforms of adhesion molecules (Neural Cell Adhesion Molecule, NCAM), and a marker of protein turnover (prealbumin, a typical indicator of caloric and protein malnutrition) were also performed. Fifty oncologic patients (28 male/22 female) and 25 non oncologic patients (18 male/7 female) (p=N.S.) were studied. In muscles from cancer patients we observed a subclinical myopathy characterized by an abnormal distribution of myonuclei. The percentage of myofibers with internalized nuclei was significantly higher in oncologic (median= 13.1%, IQR= 6.0-20.3) than in non oncologic patients (median= 3%, IQR= 2.5-6.1) (p<0.0001). The frequency of these internally nucleated myofibers is even higher in a subgroup of oncologic patients taking myotoxic drugs. In cancer patients, we observed an inverse correlation between the number of internally nucleated fibers and the presence of node metastasis (N+) (ρ)=-0.30 (p=0.03). Moreover, in patients with colorectal cancer, low serum levels of preoperative prealbumin (median= 167,7 mg/L, normal range 200-400 mg/L), were detected. The link between the observed early myopathy and long-term cachexia is supported also by the altered expression of sarcolemma associated proteins, in particular laminin and dystrophin. Patients affected with colorectal cancer at disease onset display low pre surgical serum levels of prealbumin (also known as transtiretin) and regenerating myofibers in the rectus abdominis muscle. The myopathy appears to be associated with an early stage of cancer and it could be interpreted as a consequence on the skeletal muscle of anti-cancer defense mechanisms (proapoptotic, thus non inflammatory), during the pre-invasive stage of the neoplasia. A comprehensive study on the potential molecular mechanisms that are responsible for this cancer-associated myopathy could possibly provide new diagnostic and prognostic biomarkers and new therapeutic targets to prevent the severe loss of muscle tissue which characterizes late-onset cancer cachexia." @default.
• W2188298034 created "2016-06-24" @default.
• W2188298034 creator A5062970532 @default.
• W2188298034 date "2012-01-01" @default.
• W2188298034 modified "2023-09-24" @default.
• W2188298034 title "Marcatori sierici e tissutali di miopatia nei pazienti con tumore del colon-retto al momento della diagnosi" @default.
• W2188298034 cites W1539412927 @default.
• W2188298034 cites W1967532587 @default.
• W2188298034 cites W1968177850 @default.
• W2188298034 cites W1997546274 @default.
• W2188298034 cites W2003064100 @default.
• W2188298034 cites W2004441226 @default.
• W2188298034 cites W2008869575 @default.
• W2188298034 cites W2010754117 @default.
• W2188298034 cites W2030095649 @default.
• W2188298034 cites W2037252595 @default.
• W2188298034 cites W2042971255 @default.
• W2188298034 cites W2049274197 @default.
• W2188298034 cites W2060678605 @default.
• W2188298034 cites W2065252471 @default.
• W2188298034 cites W2069565002 @default.
• W2188298034 cites W2074705421 @default.
• W2188298034 cites W2077218757 @default.
• W2188298034 cites W2077458081 @default.
• W2188298034 cites W2080490338 @default.
• W2188298034 cites W2083568101 @default.
• W2188298034 cites W2089858031 @default.
• W2188298034 cites W2091410601 @default.
• W2188298034 cites W2107089469 @default.
• W2188298034 cites W2123780581 @default.
• W2188298034 cites W2126366282 @default.
• W2188298034 cites W2129536244 @default.
• W2188298034 cites W2142237766 @default.
• W2188298034 cites W2153387767 @default.
• W2188298034 cites W2163855816 @default.
• W2188298034 cites W2165911231 @default.
• W2188298034 cites W2182282787 @default.
• W2188298034 cites W2182337922 @default.
• W2188298034 cites W2317526580 @default.
• W2188298034 cites W2414208093 @default.
• W2188298034 cites W69629398 @default.
• W2188298034 cites W2526553603 @default.
• W2188298034 hasPublicationYear "2012" @default.
• W2188298034 type Work @default.
• W2188298034 sameAs 2188298034 @default.
• W2188298034 citedByCount "0" @default.
• W2188298034 crossrefType "journal-article" @default.
• W2188298034 hasAuthorship W2188298034A5062970532 @default.
• W2188298034 hasConcept C121608353 @default.
• W2188298034 hasConcept C126322002 @default.
• W2188298034 hasConcept C142724271 @default.
• W2188298034 hasConcept C204232928 @default.
• W2188298034 hasConcept C2777300911 @default.
• W2188298034 hasConcept C2779013556 @default.
• W2188298034 hasConcept C2779959927 @default.
• W2188298034 hasConcept C526805850 @default.
• W2188298034 hasConcept C71924100 @default.
• W2188298034 hasConcept C90924648 @default.
• W2188298034 hasConceptScore W2188298034C121608353 @default.
• W2188298034 hasConceptScore W2188298034C126322002 @default.
• W2188298034 hasConceptScore W2188298034C142724271 @default.
• W2188298034 hasConceptScore W2188298034C204232928 @default.
• W2188298034 hasConceptScore W2188298034C2777300911 @default.
• W2188298034 hasConceptScore W2188298034C2779013556 @default.
• W2188298034 hasConceptScore W2188298034C2779959927 @default.
• W2188298034 hasConceptScore W2188298034C526805850 @default.
• W2188298034 hasConceptScore W2188298034C71924100 @default.
• W2188298034 hasConceptScore W2188298034C90924648 @default.
• W2188298034 hasLocation W21882980341 @default.
• W2188298034 hasOpenAccess W2188298034 @default.
• W2188298034 hasPrimaryLocation W21882980341 @default.
• W2188298034 isParatext "false" @default.
• W2188298034 isRetracted "false" @default.
• W2188298034 magId "2188298034" @default.
• W2188298034 workType "article" @default.