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- W2188298509 abstract "®was chosen as a photosensitizer (i.v. administration). Therapy dose (5 mg/kg) of photosensitizer and light was used. The experiments where performed on three experimental animal groups: the first group – rats on the 7 th day of gestation (photosensitizer administrated on 6 th day of gestation), the second group – rats on the 14 th day of gestation (photosensitizer administrated on the 13 th day of gestation) and the third one – control rats group on the 7 th day of gestation (no photosensitizer administration). Fluorescence spectroscopy methods to evaluate accumulation of a photosensitizer were used, and photobleaching of PhotofrinII ® after irradia tion was observed. Results. During our experiments it was obviously shown that photodynamic reactions appear in embryo on the 7 th day of embryogenesis while on the 14 th day of embryogenesis photobleaching of photosensitizer was not observed. Conclusions. This study showed that photodynamic reactions occur in embryo, but the pos sible effect depends on the stage of embryogenesis." @default.
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- W2188298509 date "2007-01-01" @default.
- W2188298509 modified "2023-09-24" @default.
- W2188298509 title "Spectroscopic evidence of photodynamic reactions in rat embryo and maternal tissues" @default.
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