FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188307178> ?p ?o ?g. }

• W2188307178 abstract "Background: In vitro studies suggest that reducing cholesterol inhibits HIV replication. However, this effect may not hold in vivo, where other factors, such as cholesterol's immunomodulatory properties, may interact. Methods: Fasting blood samples were obtained on 165 people living with HIV at baseline and after 24 weeks on highly active antiretroviral therapy (HAART). Participants were classified as hypocholesterolemic (HypoCHL; 150 mg/dl) and were compared on viro-immune outcomes. Results: At baseline, participants with HypoCHL (40%) exhibited lower CD4 (197 ± 181 vs. 295 ± 191 cells/mm3, p = 0.02) and CD8 (823 ± 448 vs. 1194 ± 598 cells/mm3, p = 0.001) counts and were more likely to have detectable viral loads (OR = 3.5, p = 0.01) than non-HypoCHL controls. After HAART, participants with HypoCHL were twice as likely to experience a virological failure >400 copies (95% CI 1-2.6, p = 0.05) and to exhibit <200 CD4 (95% CI 1.03-2.9, p = 0.04) compared with non-HypoCHL. Low thymic output was related to poorer CD4 cell response in HypoCHL subjects. Analyses suggest a dose-response relationship with every increase of 50 mg/dl in cholesterol related to a parallel rise of 50 CD4 cells. Conclusions: The study implicates, for the first time, HypoCHL with impaired HAART effectiveness, including limited CD4 repletion by the thymus and suboptimal viral clearance." @default.
• W2188307178 created "2016-06-24" @default.
• W2188307178 creator A5010204520 @default.
• W2188307178 creator A5012004506 @default.
• W2188307178 creator A5038438697 @default.
• W2188307178 creator A5041544237 @default.
• W2188307178 creator A5041868817 @default.
• W2188307178 creator A5047076583 @default.
• W2188307178 creator A5049295104 @default.
• W2188307178 creator A5086423747 @default.
• W2188307178 creator A5089178051 @default.
• W2188307178 creator A5091133157 @default.
• W2188307178 date "2010-01-01" @default.
• W2188307178 modified "2023-09-24" @default.
• W2188307178 title "hypocholesterolemia blunts HAART effectiveness: a longitudinal study" @default.
• W2188307178 cites W1513634422 @default.
• W2188307178 cites W1603763228 @default.
• W2188307178 cites W1639163179 @default.
• W2188307178 cites W1969435920 @default.
• W2188307178 cites W1974262140 @default.
• W2188307178 cites W1980574126 @default.
• W2188307178 cites W1982257485 @default.
• W2188307178 cites W1989375145 @default.
• W2188307178 cites W1990856526 @default.
• W2188307178 cites W1997266942 @default.
• W2188307178 cites W2000130925 @default.
• W2188307178 cites W2003813742 @default.
• W2188307178 cites W2014030143 @default.
• W2188307178 cites W2017809714 @default.
• W2188307178 cites W2024527358 @default.
• W2188307178 cites W2041863202 @default.
• W2188307178 cites W2042336247 @default.
• W2188307178 cites W2046851673 @default.
• W2188307178 cites W2061543749 @default.
• W2188307178 cites W2062025187 @default.
• W2188307178 cites W2073738273 @default.
• W2188307178 cites W2082768646 @default.
• W2188307178 cites W2088643134 @default.
• W2188307178 cites W2092495658 @default.
• W2188307178 cites W2099212163 @default.
• W2188307178 cites W2104880649 @default.
• W2188307178 cites W2106343349 @default.
• W2188307178 cites W2108982499 @default.
• W2188307178 cites W2119729821 @default.
• W2188307178 cites W2119843180 @default.
• W2188307178 cites W2130312329 @default.
• W2188307178 cites W2143854018 @default.
• W2188307178 cites W2153293610 @default.
• W2188307178 cites W2156361465 @default.
• W2188307178 cites W2172850461 @default.
• W2188307178 cites W2324695979 @default.
• W2188307178 cites W2328613271 @default.
• W2188307178 cites W2396862183 @default.
• W2188307178 cites W2786108669 @default.
• W2188307178 hasPublicationYear "2010" @default.
• W2188307178 type Work @default.
• W2188307178 sameAs 2188307178 @default.
• W2188307178 citedByCount "0" @default.
• W2188307178 crossrefType "journal-article" @default.
• W2188307178 hasAuthorship W2188307178A5010204520 @default.
• W2188307178 hasAuthorship W2188307178A5012004506 @default.
• W2188307178 hasAuthorship W2188307178A5038438697 @default.
• W2188307178 hasAuthorship W2188307178A5041544237 @default.
• W2188307178 hasAuthorship W2188307178A5041868817 @default.
• W2188307178 hasAuthorship W2188307178A5047076583 @default.
• W2188307178 hasAuthorship W2188307178A5049295104 @default.
• W2188307178 hasAuthorship W2188307178A5086423747 @default.
• W2188307178 hasAuthorship W2188307178A5089178051 @default.
• W2188307178 hasAuthorship W2188307178A5091133157 @default.
• W2188307178 hasConcept C126322002 @default.
• W2188307178 hasConcept C134018914 @default.
• W2188307178 hasConcept C140704245 @default.
• W2188307178 hasConcept C142462285 @default.
• W2188307178 hasConcept C150903083 @default.
• W2188307178 hasConcept C167672396 @default.
• W2188307178 hasConcept C203014093 @default.
• W2188307178 hasConcept C207001950 @default.
• W2188307178 hasConcept C2522874641 @default.
• W2188307178 hasConcept C26291073 @default.
• W2188307178 hasConcept C2778163477 @default.
• W2188307178 hasConcept C2778978578 @default.
• W2188307178 hasConcept C3013748606 @default.
• W2188307178 hasConcept C71924100 @default.
• W2188307178 hasConcept C86803240 @default.
• W2188307178 hasConcept C8891405 @default.
• W2188307178 hasConcept C90924648 @default.
• W2188307178 hasConceptScore W2188307178C126322002 @default.
• W2188307178 hasConceptScore W2188307178C134018914 @default.
• W2188307178 hasConceptScore W2188307178C140704245 @default.
• W2188307178 hasConceptScore W2188307178C142462285 @default.
• W2188307178 hasConceptScore W2188307178C150903083 @default.
• W2188307178 hasConceptScore W2188307178C167672396 @default.
• W2188307178 hasConceptScore W2188307178C203014093 @default.
• W2188307178 hasConceptScore W2188307178C207001950 @default.
• W2188307178 hasConceptScore W2188307178C2522874641 @default.
• W2188307178 hasConceptScore W2188307178C26291073 @default.
• W2188307178 hasConceptScore W2188307178C2778163477 @default.
• W2188307178 hasConceptScore W2188307178C2778978578 @default.
• W2188307178 hasConceptScore W2188307178C3013748606 @default.
• W2188307178 hasConceptScore W2188307178C71924100 @default.

• next