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- W2188313623 abstract "ABSTRACT Geraylgeranylated Rabproteinsusually ter- minate In either Cys-CysorCys-Xaa-Cys, whereXaais Ala, Ser, or Gly. In bothcdasesofproteins, the twocysteines are geranylgeranylated, butonly the Cys-Xaa-Cysclass hasbeen shownto becarboxyl-methylated on the terminal cysteine in Wvo. In the current study, we used recombinant Rabgera-nylgeranyltransferase and a Rab escort protein (REP-1) to attach geranylgeranyl residues to the two cysteines at the carboxyl termius ofRab3A(Cys-Ala-Cys) andRablA(Cys-Cys). The geranylgeranylated proteins were then incubatedwithbovinecerebeflarmembranes that contain an enzyme that trsfers [3Hlmethyl from S-[methyl-3PHadenosyl-L-methio- nine to geranylgeranylated cysteine. The enzymetransferred [3Hhmethyl to geranylgeranylated Rab3A but not to gera-nylgeranylated RablA. Replacement of the Cys-Ala-Cys ter- minusofRab3AwithCys-Cysabolishedmethylatlon, andthe opposite resultwas obtainedwhen the Cys-CysofRablA was replaced with Cys-Ala-Cys. When -the Cys-Cys terminus ofRablA was changed" @default.
- W2188313623 created "2016-06-24" @default.
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- W2188313623 date "1994-01-01" @default.
- W2188313623 modified "2023-09-27" @default.
- W2188313623 title "Geranylgeranylated Rabproteins terminating inCys-Ala-Cys, but notCys-Cys, arecarboxyl-methyla" @default.
- W2188313623 hasPublicationYear "1994" @default.
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