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• W2188331101 abstract "Objective: To assess the effect of leukemia therapy on the cerebrospinal fluid (CSF) antioxidant and oxidant status in children with acute lymphoblastic leukemia (ALL). Material and Method: Twenty-four consecutive children (15 boys and 9 girls) newly diagnosed with ALL were enrolled in the study. CSF concentrations of ceruloplasmin ferroxidase activity, total thiol group, lipid hydroperoxide (LOOH) and total oxidant status (TOS) were evaluated at diagnosis, remission induction, consolidation, continuation, and the end of the continuation. Nineteen children (10 boys and 9 girls) were enrolled as a reference group. Results: The study group at diagnosis had significant higher mean ferroxidase activity (50.2 ± 10.4 U/L and 30.3 ± 7.9 U/L), total thiol (0.34 ± 0.02 µmol/L and 0.18 ± 0.01 µmol/L), LOOH (6.5 ± 1.9 µmol/L and 5.3 ± 0.8 µmol/L), and TOS (9.3 ± 4.3 µmol H O equiv./L and 6 ± 1.5 H O equiv./L) levels compared with the 2 2 2 2 references, respectively (P < 0.05).. Ferroxidase activity remained elevated during the entire treatment course. Total thiol levels stayed elevated from diagnosis to week 80 of ALL treatment and significantly decreased thereafter. LOOH levels were progressively increased to week 80 of the treatment course. TOS levels were progressively decreased two times at continuation week 7 and end of the treatment. Conclusions: Our data indicate that CSF oxidative stress and antioxidants are higher at diagnosis, significant changes to be during therapy, and is already high at the end of therapy in children with ALL." @default.
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• W2188331101 date "2014-08-01" @default.
• W2188331101 modified "2023-10-03" @default.
• W2188331101 title "Cerebrospinal fluid oxidant/antioksidant status in children with acute lymphoblastic leukemia" @default.
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