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• W2188340488 abstract "Oral delivery of poorly water - soluble drugs creates critical problem for their formulation as 35 - 40% of new active pharmaceutical ingredients have poor water solubility and frequently associated with low bioavailability. Recently much at tention has been given to lipid - based formulation with particular emphasis on self emulsifying drug delivery system (SEDDS) to improve the oral bioavailability. These can exist in either liquid or solid states. Self - emulsifying system formulation mainly de pends on the nature of oil/lipid excipients, surfactants, their concentration and temperature at which emulsification occurs. As advancement or substitute of conventional liquid SEDDS, Solid SEDDS are better in minimizing manufacturing cost, makes simpler industrial manufacture, enhancing stability, patient compliance and most prominently these are very flexible to develop different solid dosage forms for oral and parentral administration. In addition, such formulation prevents GI irritation and able to co ntrol drug release. Recently self emulsifying drug delivery system is used as an efficient approach for the formulation of drugs that are beneficial in the diseases such as hypertension and congestive heart failure, HIV infections, cancer etc. The main dif ficulty in the development of SEDDS and other lipid - based formulations is the lack of high - quality in vitro models for their evaluation . Finally, the existing problems and the possible future research directions in this field are pointed out ." @default.
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• W2188340488 date "2011-01-01" @default.
• W2188340488 modified "2023-09-26" @default.
• W2188340488 title "SELF EMUL SIFYING DRUG DELIVERY SYSTEM: HITHERTO AND RECENT ADVANCES" @default.
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