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• W2188351036 abstract "6cycles. Half of each beam was bulk stained in basic fuchsin. From the loaded area, three 100µm sections were taken near the fracture site and one 5mm segment was taken next to these sections. Three additional 100µm sections and another 5mm segment were taken from the unloaded region beyond the outer supports. The 100 µm sections from the unloaded area were used to determine the pre-test microdamage level (microcrack density, length, and surface density), while the sections from the loaded area were used to determine post-test microdamage levels, porosity, and amount of remodeling. The 5 mm segments were used to determine beam density and degree of mineralization. In the current study, fatigue resistance is defined as the ability of bone to resist an increase in microdamage. Microdamage was physically measured as the number of cracks per unit area (crack density), as well as the total length of cracks per unit area (crack damage) [5]. Stepwise regressions were performed for change in crack density and change in crack damage using the following independent variables: age, porosity, wet density, dry density, mineralization, log of cumulative strain, preexisting crack density, and pre-existing crack damage. Pre-existing crack density and damage were only used in the regressions for change in crack density and change in crack damage, respectively. Cumulative strain, here defined as 2*(number of cycles)*(initial strain range), is commonly used as a variable to represent how much a specimen is loaded. It takes into account both the strain level and the number of cycles to which the specimen is loaded. Results Both regressions yielded similar results. Both measures of increasing damage were significantly affected by the subject’s age, as well as the bone porosity and log of cumulative strain applied to the specimen. Additionally, for each measure of damage, the increase was negatively correlated to the amount initially present. The regression coefficients and significance levels for the models are presented in Table 1. Discussion Crack density and crack damage are direct physical measures of the amount of microdamage in cortical bone. Crack damage takes into account both crack density and length. It is notable" @default.
• W2188351036 created "2016-06-24" @default.
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• W2188351036 date "2000-01-01" @default.
• W2188351036 modified "2023-09-24" @default.
• W2188351036 title "EFFECTS OF FATIGUE LOADING ON MICRODAMAGE IN HUMAN CORTICAL BONE" @default.
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