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- W2188367010 abstract "Melanoma development not only involves genetic and epigenetic changes that take place within the cell, but als o involves processes determined collectively by micro-environ mental factors, including cell-cell interactions and communic a - tions. During the transition from normal cells to benign and malignant lesions, and subsequently to metastatic cancer, stepwis e changes in intercellular communications provide tumor cells with the ability to overcome cell-cell adhesion and micro-env i - ronmental controls from the host and to invade surrounding tissues and disperse to distant locations. Cadherins are majo r cell-cell adhesion molecules involved in the development and maintenance of skin. E-cadherin expressed in norma l melanocytes mediates growth and invasion control by keratinocytes. Progressive loss of E-cadherin and gain of N-cadheri n during melanoma development not only free melanoma cells from control by keratinocytes, but also provide new adhesio n properties, resulting in switched partnerships with fibroblasts and vascular endothelial cells. The cadherin subtype switchin g also dictates gap junctional specificity in melanocytic cells during tumor development. This selective intercellular communic a - tion may contribute to the regulation of cell growth, differentiation, apoptosis, and migration of melanocytic cells in both phy s - iologic and pathologic conditions. Abnormal up-regulation of the immunoglobin repeat-containing cell adhesion molecule s Mel-CAM and L1-CAM potentiates invasion and migration of melanoma. Thus, abnormal expression of intercellular adhesio n receptors and dysregulated intercellular communication underlies melanoma development and progression ." @default.
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- W2188367010 date "2002-01-01" @default.
- W2188367010 modified "2023-09-26" @default.
- W2188367010 title "DYNAMIC SO F CEL L I NTERACTION S AN D COMMUNICATION S DURIN GMELANOM A DEVELOPMEN T" @default.
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