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- W2188412449 abstract "Oxidative stress is closely related to all aspects of cancer, from carcino- genesis to the tumor-bearing state, from treatment to prevention. The human body is constantly under oxidative stress arising from exogenous origins (e.g., ultraviolet rays) and endogenous origins (at the cellular level where mitochondria are involved). When such oxidative stress exceeds the capacity of the oxidation-reduction system of the body, gene mutations may result or intracellular signal transduction and transcription factors may be affected directly or via antioxidants, leading to carcino- genesis. The tumor-bearing state is also said to be under oxidative stress associ- ated with active oxygen production by tumor cells and abnormal oxidation-reduction control. One of the mechanisms by which anticancer agents and radiation therapy exert their effects is through apoptosis of cancer cells. Oxidative stress is also involved in the problem of resistance to these treatments. The efficacy of anti- oxidants in the prevention of carcinogenesis is currently under investigation. Issues to be addressed in the future include the establishment of easy, accurate methods of measurement and evaluation of the extent of oxidative stress in the body as well as the clinical application of experimentally obtained knowledge to the prevention and treatment of cancer." @default.
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- W2188412449 date "2001-01-01" @default.
- W2188412449 modified "2023-09-23" @default.
- W2188412449 title "Cancer and Oxidative Stress" @default.
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