Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188449093> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2188449093 endingPage "2621" @default.
- W2188449093 startingPage "2609" @default.
- W2188449093 abstract "MDL 29311 is an antioxidant that lowers plasma triglycerides and raises high density lipoprotein (HDL) cholesterol in rats. It lowers triglycerides in rats by enhancing the clearance of very low density lipoprotein (VLDL) by the liver (Sheetz, M. J., et al. 1994. Metabolism. 43: 232-240). In this paper, the possibility that MDL 29311 enhances VLDL clearance by altering the apolipoprotein (apo) content of lipoproteins is examined. Treatment of rats with 1% MDL 29311 in the diet for 7 days lowered plasma triglycerides and markedly increased total lipoprotein-associated apoE. The increase in apoE was confined to the HDL fraction; no increase in VLDL-associated apoE was detected. No apparent alterations in the amount of total lipoprotein-associated apoC were observed, although there was a decrease in VLDL-associated apoC-II and C-III-0. Consistent with this finding, the amount of 125I-labeled apoC transferred from HDL to VLDL in plasma from MDL 29311-treated rats was only 40% of the amount transferred in control plasma. Sepharose 6B gel filtration of mixtures of 125I-labeled apoC with increasing concentrations of MDL 29311 in the absence of plasma or lipid revealed that proportionally increasing amounts of the 125I-labeled apoC eluted in a high molecular weight (HMW) complex with MDL 29311. An HMW complex was not formed when MDL 29311 was mixed with 125I-labeled soybean trypsin inhibitor. The 125I-labeled apoC in the HMW complex bound to VLDL only 20% as well as uncomplexed 125I-labeled apoC. MDL 29311 also caused the dissociation of 125I-labeled apoC from VLDL at concentrations of MDL 29311 similar to those obtained in vivo. Other phenolic antioxidants related to MDL 29311 caused the formation of HMW 125I-labeled apoC-containing complexes to an extent proportional to their abilities to lower triglycerides in rats. These studies support the hypothesis that MDL 29311 lowers triglycerides in rats by interfering with apoC association with VLDL, thereby relieving the apoC-mediated inhibition of hepatic VLDL uptake." @default.
- W2188449093 created "2016-06-24" @default.
- W2188449093 creator A5072327491 @default.
- W2188449093 date "1995-12-01" @default.
- W2188449093 modified "2023-09-24" @default.
- W2188449093 title "MDL 29311, a phenolic antioxidant, interferes with the interaction of apoC with VLDL: a possible explanation for its triglyceride-lowering effect." @default.
- W2188449093 cites W1530975353 @default.
- W2188449093 cites W1546008389 @default.
- W2188449093 cites W1963872182 @default.
- W2188449093 cites W1969927159 @default.
- W2188449093 cites W2007835979 @default.
- W2188449093 cites W2008791058 @default.
- W2188449093 cites W2011819665 @default.
- W2188449093 cites W2020686577 @default.
- W2188449093 cites W2022332493 @default.
- W2188449093 cites W2033886436 @default.
- W2188449093 cites W2034968148 @default.
- W2188449093 cites W2042436608 @default.
- W2188449093 cites W2047070188 @default.
- W2188449093 cites W2048075930 @default.
- W2188449093 cites W2057471793 @default.
- W2188449093 cites W2084744450 @default.
- W2188449093 cites W2085635594 @default.
- W2188449093 cites W2085649019 @default.
- W2188449093 cites W2095885613 @default.
- W2188449093 cites W2096773810 @default.
- W2188449093 cites W2100098015 @default.
- W2188449093 cites W2275369971 @default.
- W2188449093 cites W2401829918 @default.
- W2188449093 cites W2403507619 @default.
- W2188449093 cites W4297681290 @default.
- W2188449093 cites W58112070 @default.
- W2188449093 doi "https://doi.org/10.1016/s0022-2275(20)41097-1" @default.
- W2188449093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8847487" @default.
- W2188449093 hasPublicationYear "1995" @default.
- W2188449093 type Work @default.
- W2188449093 sameAs 2188449093 @default.
- W2188449093 citedByCount "1" @default.
- W2188449093 crossrefType "journal-article" @default.
- W2188449093 hasAuthorship W2188449093A5072327491 @default.
- W2188449093 hasBestOaLocation W21884490931 @default.
- W2188449093 hasConcept C185592680 @default.
- W2188449093 hasConcept C2778004101 @default.
- W2188449093 hasConcept C2778163477 @default.
- W2188449093 hasConcept C2778913445 @default.
- W2188449093 hasConcept C2780072125 @default.
- W2188449093 hasConcept C31903555 @default.
- W2188449093 hasConcept C55493867 @default.
- W2188449093 hasConcept C8243546 @default.
- W2188449093 hasConceptScore W2188449093C185592680 @default.
- W2188449093 hasConceptScore W2188449093C2778004101 @default.
- W2188449093 hasConceptScore W2188449093C2778163477 @default.
- W2188449093 hasConceptScore W2188449093C2778913445 @default.
- W2188449093 hasConceptScore W2188449093C2780072125 @default.
- W2188449093 hasConceptScore W2188449093C31903555 @default.
- W2188449093 hasConceptScore W2188449093C55493867 @default.
- W2188449093 hasConceptScore W2188449093C8243546 @default.
- W2188449093 hasIssue "12" @default.
- W2188449093 hasLocation W21884490931 @default.
- W2188449093 hasOpenAccess W2188449093 @default.
- W2188449093 hasPrimaryLocation W21884490931 @default.
- W2188449093 hasRelatedWork W102955919 @default.
- W2188449093 hasRelatedWork W1999287894 @default.
- W2188449093 hasRelatedWork W2011708482 @default.
- W2188449093 hasRelatedWork W2047407416 @default.
- W2188449093 hasRelatedWork W2087937805 @default.
- W2188449093 hasRelatedWork W2134715975 @default.
- W2188449093 hasRelatedWork W236548497 @default.
- W2188449093 hasRelatedWork W2443856458 @default.
- W2188449093 hasRelatedWork W2588417043 @default.
- W2188449093 hasRelatedWork W2588152834 @default.
- W2188449093 hasVolume "36" @default.
- W2188449093 isParatext "false" @default.
- W2188449093 isRetracted "false" @default.
- W2188449093 magId "2188449093" @default.
- W2188449093 workType "article" @default.