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• W2188491012 abstract "Adenocarcinomas of the lung remain a significant public health problem. Locally defined (stage I) tumors are considered amenable to resection with curative intent. However, only about 45% of these patients survive for S years. The median survival for more advanced tumors is drastically lower. Much research has been focusedon identifying a valid genetic biomarker of prognosis. Mutations of the proto-oncogene KRAS have been identified by some groups as being a valid prognostic indicator for adenocarcinoma of the lung. To evaluate the effect of KRAS gene mutation on the survival of patients with lung adenocarcinoma, 181 archival tumors were examined by PCR and denaturing gradient gel ebectrophoresis. Mutations in either codon 12 or 13 were found in 31.5% of the samples. The most common mutation was a G-*T transversion in codon 12, representing 66.7% of the mutations. No difference was observed in the survival of patients with a" @default.
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• W2188491012 date "1997-01-01" @default.
• W2188491012 modified "2023-09-24" @default.
• W2188491012 title "Prognostic Value of Specific KRAS Mutations in Lung" @default.
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