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- W2188503457 abstract "Arteriovenous carbon dioxide removal (AVCOzR) by a low-resistance gas exchanger in a simple arteriovenous shunt is capable of achieving near total COz removal and lung rest during ARDS. We evaluated AVCOzR effect on a LDS0 smokehurn (36 breath, 40% Illo TBSA) ARDS model in a prospective, randomized, controlled, unblinded l-day outcomes study of ventilator free days and survival. All AVC02R sheep survived, while only 2 SHAM animals survived the I-day study. AVCOzR bad 2.4 ventilator dependent days versus 6.5 days with SHAM. For our initial patient experience, 5 adults in unresponsive, severe ARDS were successfully cannulated for AVCOZR at bedside and completed the 72-h trial and 3/5 patients were discharged. AVC02R removed approximately 70% of CO2. Changes in ventilator parameters from baseline to 48 h included a decrease in tidal volume, peak inspiratory pressure, minute ventilation, and respiratory rate. Next, a hefore-after study of AVCOzR was performed on 8 subjects with ARDS. PaCOZ decreased significantly despite a decrease in minute ventilation from baseline and normalization of pH. We propose the normalization of COz and decreased minute Ventilation allows amelioration of the pathophysiology of ARDS. Keywords - ARDS, Arteriovenous COz removal, mechanical ventilation" @default.
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- W2188503457 date "2002-01-01" @default.
- W2188503457 modified "2023-09-27" @default.
- W2188503457 title "ARTERIO VENOUS CARBOS DIOXIDE REMOVAL (AVCOzR) FOR SEVERE RESPIRATORY FAILURE" @default.
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