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• W2188527694 abstract "vs. 41 ± 17 years, p = 0.04), PRA levels ≥ 25% (16.7% vs. 3.1%, p = 0.07) and previous rejection events (21.4% vs. 5.3%, p = 0.08). Diffuse glomerular lesions were observed in all TMA cases, with capillary congestion (100 vs. 35.1%, p < 0.01), microthrombi (50% vs. 5.4, p = 0.01), schistocytes (42.8% vs. 7.7%, p = 0.01) and mesangiolysis (85.7% vs. 29.7%, p < 0.01). Positive C4d in de novo TMA cases was similar to TG (71.4% vs. 53.8%, p = ns) but presented arteriolar C4d deposition (35.7 % vs. 8.7%, p = 0.042). Donor -specific antibodies detection was equally found (TG: 41.6%; TMA: 57.1%, p = ns), mainly anti -HLA Class II. In ultrastructural analysis only TG cases presented glomerular basement membrane (GBM) mul- tilayering. Graft loss was similar, but de novo MAT cases had worst first year survival (73.3% vs. 97%, p = 0.013). Conclusion: Both pathologies belong within the spectrum of microcirculatory injury: TG results from subclinical lesion, presenting chronic cyclic accommodation, de novo TMA represents severe form of lytic endothelial lesion." @default.
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• W2188527694 date "2014-01-01" @default.
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• W2188527694 title "Transplant glomerulopathy and post-transplant de novo thrombotic microangiopathy: common features and pathologic mechanisms Glomerulopatia do transplante e microangiopatia trombótica de novo pós transplante: morfologia e mecanismos patológicos" @default.
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