Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188544498> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2188544498 endingPage "22" @default.
- W2188544498 startingPage "17" @default.
- W2188544498 abstract "Peritoneal dissemination of cancer involves several steps, including tumor cell attachment, invasion and growth in the peritoneum. Tumor angiogenesis is a prerequisite for the growth of disseminated tumor. Vascular endothelial growth factor (VEGF) and its receptor are major regulators of angiogenesis.We examined the cytotoxic effects of SU6668, an inhibitor of VEGF tyrosine kinase receptors, on in vitro gastric cancer cell lines and human umbilical vascular endothelial cells (HUVEC); we also examined the antitumor effects of SU6668 on human gastric cancer cells administered intraperitoneally into nude mice.Direct cytotoxicity to gastric cancer cells (TMK-1, MKN-45 and MKN-74) and normal cells (HUVEC) was determined by the MTT assay and the bromodeoxyuridine (BrdU) incorporation assay, with and without VEGF-evoked growth stimulation in vitro. TMK-1 cells were transplanted intraperitoneally into nude mice, followed by twice daily oral administration of SU6668 (200 mg/kg/day) for two weeks starting on the first day after transplantation. Both the number and the wet weight of disseminated peritoneal tumor nodules were assessed.In the MTT assay, SU6668 demonstrated low-grade cytotoxicity to the cell growth of three gastric cancer cells, with a 50% inhibitory concentration (IC50) of 22.6 microg/ml for TMK-1, 31.8 microg/ml for MKN-45 and 26.7 microg/ml for MKN-74; HUVEC was sensitive to SU6668 with an IC50 of 8.9 microg/ml. In the BrdU assay, VEGF stimulated DNA synthesis in HUVEC, while the incorporation of BrdU was not affected by VEGF in gastric cancer cell lines. SU6668 inhibited VEGF-induced DNA synthesis in HUVEC, while BrdU incorporation of gastric cancer cell lines was inhibited by SU6668 without correlation to VEGF stimulation. Peritoneal dissemination of cancer in nude mice was significantly suppressed by SU6668 compared with a control group at the p<0.05 level.The mechanism of the antitumor activity of SU6668 may not involve direct toxicity to cancer cells, but may rather be an inhibitory effect on tumor angiogenesis, resulting in the inhibition of tumor dissemination in the peritoneum." @default.
- W2188544498 created "2016-06-24" @default.
- W2188544498 creator A5020608796 @default.
- W2188544498 creator A5043888002 @default.
- W2188544498 creator A5044279752 @default.
- W2188544498 creator A5045197572 @default.
- W2188544498 creator A5048945082 @default.
- W2188544498 creator A5061916723 @default.
- W2188544498 creator A5078489994 @default.
- W2188544498 creator A5079517184 @default.
- W2188544498 date "2005-04-09" @default.
- W2188544498 modified "2023-09-25" @default.
- W2188544498 title "Tyrosine kinase inhibitor SU6668 inhibits peritoneal dissemination of gastric cancer via suppression of tumor angiogenesis." @default.
- W2188544498 cites W121768262 @default.
- W2188544498 cites W1581914061 @default.
- W2188544498 cites W1593130318 @default.
- W2188544498 cites W1969565308 @default.
- W2188544498 cites W1989655840 @default.
- W2188544498 cites W2111517972 @default.
- W2188544498 cites W2114918609 @default.
- W2188544498 cites W2160930114 @default.
- W2188544498 cites W2170285778 @default.
- W2188544498 cites W2189275381 @default.
- W2188544498 cites W2308973955 @default.
- W2188544498 cites W2336451035 @default.
- W2188544498 cites W2394591386 @default.
- W2188544498 cites W2412249834 @default.
- W2188544498 cites W36457412 @default.
- W2188544498 cites W95069854 @default.
- W2188544498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15816514" @default.
- W2188544498 hasPublicationYear "2005" @default.
- W2188544498 type Work @default.
- W2188544498 sameAs 2188544498 @default.
- W2188544498 citedByCount "4" @default.
- W2188544498 countsByYear W21885444982016 @default.
- W2188544498 crossrefType "journal-article" @default.
- W2188544498 hasAuthorship W2188544498A5020608796 @default.
- W2188544498 hasAuthorship W2188544498A5043888002 @default.
- W2188544498 hasAuthorship W2188544498A5044279752 @default.
- W2188544498 hasAuthorship W2188544498A5045197572 @default.
- W2188544498 hasAuthorship W2188544498A5048945082 @default.
- W2188544498 hasAuthorship W2188544498A5061916723 @default.
- W2188544498 hasAuthorship W2188544498A5078489994 @default.
- W2188544498 hasAuthorship W2188544498A5079517184 @default.
- W2188544498 hasConcept C121608353 @default.
- W2188544498 hasConcept C153911025 @default.
- W2188544498 hasConcept C167734588 @default.
- W2188544498 hasConcept C170493617 @default.
- W2188544498 hasConcept C203014093 @default.
- W2188544498 hasConcept C2775960820 @default.
- W2188544498 hasConcept C2777025900 @default.
- W2188544498 hasConcept C2780394083 @default.
- W2188544498 hasConcept C2780783641 @default.
- W2188544498 hasConcept C502942594 @default.
- W2188544498 hasConcept C54355233 @default.
- W2188544498 hasConcept C55493867 @default.
- W2188544498 hasConcept C62112901 @default.
- W2188544498 hasConcept C86803240 @default.
- W2188544498 hasConcept C96232424 @default.
- W2188544498 hasConceptScore W2188544498C121608353 @default.
- W2188544498 hasConceptScore W2188544498C153911025 @default.
- W2188544498 hasConceptScore W2188544498C167734588 @default.
- W2188544498 hasConceptScore W2188544498C170493617 @default.
- W2188544498 hasConceptScore W2188544498C203014093 @default.
- W2188544498 hasConceptScore W2188544498C2775960820 @default.
- W2188544498 hasConceptScore W2188544498C2777025900 @default.
- W2188544498 hasConceptScore W2188544498C2780394083 @default.
- W2188544498 hasConceptScore W2188544498C2780783641 @default.
- W2188544498 hasConceptScore W2188544498C502942594 @default.
- W2188544498 hasConceptScore W2188544498C54355233 @default.
- W2188544498 hasConceptScore W2188544498C55493867 @default.
- W2188544498 hasConceptScore W2188544498C62112901 @default.
- W2188544498 hasConceptScore W2188544498C86803240 @default.
- W2188544498 hasConceptScore W2188544498C96232424 @default.
- W2188544498 hasIssue "1A" @default.
- W2188544498 hasLocation W21885444981 @default.
- W2188544498 hasOpenAccess W2188544498 @default.
- W2188544498 hasPrimaryLocation W21885444981 @default.
- W2188544498 hasRelatedWork W1968123283 @default.
- W2188544498 hasRelatedWork W2030704466 @default.
- W2188544498 hasRelatedWork W2079688193 @default.
- W2188544498 hasRelatedWork W2150529368 @default.
- W2188544498 hasRelatedWork W2198122211 @default.
- W2188544498 hasRelatedWork W2358956776 @default.
- W2188544498 hasRelatedWork W2391192429 @default.
- W2188544498 hasRelatedWork W24668930 @default.
- W2188544498 hasRelatedWork W2892707925 @default.
- W2188544498 hasRelatedWork W2901740467 @default.
- W2188544498 hasVolume "25" @default.
- W2188544498 isParatext "false" @default.
- W2188544498 isRetracted "false" @default.
- W2188544498 magId "2188544498" @default.
- W2188544498 workType "article" @default.