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- W2188557118 abstract "Hgh performance liquid chromatography has shown thatafterintravenous injection cholesterol-poor liposomes(100nm)are un- stable andtheir phospholipid isredistributed. Underidentical conditions cholesterol-rich liposomes remainstructurally intact within thecirculation. Wheninjected intravenously cholesterol-rich liposomes accumulate within theinflamed paws ofratswithadjuvant induced arthritis to thesame extentas cholesterol-poor liposomes. Uptakeinin- flamedtissue ofthreecholesterol-rich lipo- some preparations was alwayssignificantly greaterthantheuptakenotedinnormal tissue. Thedegree ofaccumulation ininflamed tissue was foundtodepend on thesizeofthe liposome, withthegreatest uptake, 7%ofthe injected dose, achieved bythesmallest vesicle (100nm).Theseresults indicate thatintact liposomes accumulate atinflamed joint tissue sites. Therefore thepassive targeting ofanti- inflammatory drugs encapsulated within these liposomes couldbecontemplated." @default.
- W2188557118 created "2016-06-24" @default.
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- W2188557118 date "1990-01-01" @default.
- W2188557118 modified "2023-09-27" @default.
- W2188557118 title "Specific accumulation ofcholesterol-rich liposomes intheinflammatory tissueofratswithadjuvant arthritis" @default.
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