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• W2188583399 endingPage "179" @default.
• W2188583399 startingPage "169" @default.
• W2188583399 abstract "ABSTRACT The role of basal epithelial cells in prostatic function, development and carcinogenesis is unknown. The ability of basal prostatic epithelial cells to acquire a luminal phenotype was explored in vitro using the NRP-152 rat dorsal-lateral prostate epithelial cell line as a model system. NRP-152, which was spontaneously immortalized and clonally derived, is an androgen-responsive and nontumorigenic cell line that has a basal cell phenotype under normal growth conditions. However, when placed in mitogen-deficient media, these cells undergo a dramatic morphological change to a luminal phenotype. Under these growth-restrictive conditions, immunocytochemical analysis shows that NRP-152 cells acquire the luminal markers Z0-1 (a tight-junction associated protein), occludin (integral tight-junction protein), and cytokeratin 18, and lose the basal markers cytokeratins 5 and 14. Total protein and mRNA levels of cytokeratins 8, 18, c-CAM 105 (the calcium-independent cell adhesion molecule) and Z0-1, as detected by western and/or northern blot analyses, respectively, are induced, while cytokeratin 5 and 15 are lost, and occludin is unchanged. Concomitant with this differentiation, expression of transforming growth factor-beta 2 (TGF-2), TGF-3, and TGF- receptor type II (TRII) is induced, while those of TGF-1 and TRI remain essentially unchanged. Mitogens, such as insulin-like growth factor-I and dexamethasone inhibit luminal differentiation, while exogenous TGF- induces such differentiation. These data together with TGF- neutralization experiments using pan-specific antibody implicate an important role for autocrine TGF- in the induction of the luminal differentiation." @default.
• W2188583399 created "2016-06-24" @default.
• W2188583399 creator A5058446859 @default.
• W2188583399 date "1999-01-15" @default.
• W2188583399 modified "2023-09-30" @default.
• W2188583399 title "Transdifferentiation of NRP-152 rat prostatic basal epithelial cells toward a luminal phenotype: regulation by glucocorticoid, insulin-like growth factor-I and transforming growth factor-beta" @default.
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• W2188583399 doi "https://doi.org/10.1242/jcs.112.2.169" @default.
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