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• W2188592022 abstract "Acne is a common disease of the pilosebaceous units of the skin and topical therapy is recommended for the management of acne with comedolytic, anti-inflammatory agents, along with antimicrobials. However, topical application of these drugs leads to frequent adverse effects and also, there is an emergence of antibiotic resistance by Propionibacterium acnes. Furthermore, systemic antimicrobial usage has been causally associated with various adverse events. Clarina cream is a polyherbal formulation and contains extracts of Aloe barbadensis, Prunus amygdalus, Alternanthera sessilis and Rubia cordifolia, and the present study was planned to evaluate the efficacy and safety of Clarina cream in management of acne vulgaris. This study was an open, non-comparative clinical trial conducted at the Department of Dermatology of V. S. Medical College, Ahmedabad, from January to April 2002. Twenty eight patients of both sexes were included in the study. Children below 18 years of age, patients with preexisting systemic disease necessitating long-term medications, genetic and endocrinal disorders and those who refused to give informed consent were excluded from the study. Pregnant and lactating women were also excluded from the study. A baseline history was obtained in order to determine the patient’s eligibility for enrolment in the trial. Thereafter all patients underwent a clinical examination and thorough skin examination was done. All patients were advised to apply Clarina cream topically over the lesions, twice a day for a period of 6 weeks. All patients were followed up every two weeks and during each follow-up visit, local skin examination was done. The predefined primary outcome measures were reduction in number of blackheads, whiteheads, inflamed pustules and overall inflammation along with increase in exfoliation, overall moisturizing and soothing effects and healing without scar formation. The predefined secondary outcome measures were incidence of adverse events and compliance to the treatment. Statistical analysis was done according to intention-to-treat principles. This study observed significant improvement in the mean scores for reduction in number of blackheads, whiteheads, inflamed pustules and overall inflammation. In addition, there was significantly better exfoliation, moisturizing and soothing effects, along with significant improvement in healing without scar formation. The overall response to the treatment also recorded a significant improvement from the second week onwards. There were no clinically significant short- and long-term adverse reactions (either reported or observed) , during the entire period of study and excellent patient compliance to Clarina cream was also observed. Based on these observations, it may be concluded that Clarina cream is clinically effective and safe for short- and long-term usage in acne vulgaris." @default.
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• W2188592022 date "2004-01-01" @default.
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• W2188592022 title "Evaluation of efficacy and safety of Clarina cream in newly diagnosed and previously treated cases of acne vulgaris" @default.
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