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- W2188626362 abstract "RESEARCH DESIGN AND METHODSdCase and control subjects were selected from the PREVEND cohort, a large (n = 8,592), prospective general population study on the natural course of albuminuria, with .10 years of follow-up and repeated albuminuria measurements. We found 24 T2DM and 50 HT case subjects transitioning from normo- to macroalbuminuria and 9 T2DM and25 HT case subjects transitioningfrommicro- tomacroalbuminuria (average follow-up 2.8 years). Control subjects with stable albuminuria were pair matched for age, sex, albuminuria status, and diabetes duration. GDF-15 was measured in samples prior to albuminuria transition. RESULTSdPrior to transition, GDF-15 was significantly higher in case subjects with T2DM than in control subjects (median [IQR] 1,288 pg/mL [885–1,546] vs. 948 pg/mL [660–1,016], P,0.001).TheoddsratiofortransitioninalbuminuriaincreasedsignificantlyperSDofGDF-15 (2.9 [95% CI 1.1–7.5], P = 0.03). GDF-15 also improved prediction of albuminuria transition, withsignificantincreasesinCstatistic(from0.87to0.92,P=0.03)andintegrateddiscrimination improvement (0.148, P= 0.001). In HT, GDF-15 was also independently associated with transition in albuminuria stage (2.0 [1.1–3.5], P = 0.02) and improved prediction significantly. CONCLUSIONSdWe identified GDF-15 as a clinically valuable marker for predicting transition in albuminuria stage in T2DM beyond conventional risk markers. These findings were confirmed in nondiabetic HT subjects. Diabetes Care 35:2340–2346, 2012" @default.
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- W2188626362 date "2012-01-01" @default.
- W2188626362 modified "2023-09-28" @default.
- W2188626362 title "iation Factor 15 Predicts Worsening of Albuminuria in Patients With Type 2 Diabetes" @default.
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