Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188651479> ?p ?o ?g. }
- W2188651479 abstract "Diabetic retinopathy (DR) and diabetic macular edema (DME) are leading causes of blindness in the working-age population of most developed countries. The increasing number of individuals with diabetes worldwide suggests that DR and DME will continue to be major contributors to vision loss and associated functional impairment for years to come. Early detection of retinopathy in individuals with diabetes is critical in preventing visual loss, but current methods of screening fail to identify a sizable number of high-risk patients. The control of diabetesassociated metabolic abnormalities (i.e., hyperglycemia, hyperlipidemia, and hypertension) is also important in preserving visual function because these conditions have been identified as risk factors for both the development and progression of DR/DME. The currently available interventions for DR/DME, laser photocoagulation and vitrectomy, only target advanced stages of disease. Several biochemical mechanisms, including protein kinase C‐ activation, increased vascular endothelial growth factor production, oxidative stress, and accumulation of intracellular sorbitol and advanced glycosylation end products, may contribute to the vascular disruptions that characterize DR/DME. The inhibition of these pathways holds the promise of intervention for DR at earlier non‐sight-threatening stages. To implement new therapies effectively, more individuals will need to be screened for DR/DME at earlier stages—a process requiring both improved technology and interdisciplinary cooperation among physicians caring for patients with diabetes." @default.
- W2188651479 created "2016-06-24" @default.
- W2188651479 creator A5047403985 @default.
- W2188651479 creator A5073240119 @default.
- W2188651479 creator A5090437675 @default.
- W2188651479 date "2003-01-01" @default.
- W2188651479 modified "2023-09-24" @default.
- W2188651479 title "Diabetic Retinopathy and Diabetic" @default.
- W2188651479 cites W1255933066 @default.
- W2188651479 cites W130253034 @default.
- W2188651479 cites W1518569938 @default.
- W2188651479 cites W1519698956 @default.
- W2188651479 cites W1522407811 @default.
- W2188651479 cites W1525822147 @default.
- W2188651479 cites W1529592271 @default.
- W2188651479 cites W1565530759 @default.
- W2188651479 cites W1591039074 @default.
- W2188651479 cites W161640613 @default.
- W2188651479 cites W1810991871 @default.
- W2188651479 cites W193642471 @default.
- W2188651479 cites W1964257010 @default.
- W2188651479 cites W1966234811 @default.
- W2188651479 cites W1966419887 @default.
- W2188651479 cites W1967172766 @default.
- W2188651479 cites W1971325624 @default.
- W2188651479 cites W1976704017 @default.
- W2188651479 cites W1977070873 @default.
- W2188651479 cites W1977323463 @default.
- W2188651479 cites W1977628080 @default.
- W2188651479 cites W1980534597 @default.
- W2188651479 cites W1981497203 @default.
- W2188651479 cites W1982722705 @default.
- W2188651479 cites W1983964043 @default.
- W2188651479 cites W1984590014 @default.
- W2188651479 cites W1988143227 @default.
- W2188651479 cites W1990675333 @default.
- W2188651479 cites W1990773395 @default.
- W2188651479 cites W1995861596 @default.
- W2188651479 cites W1997103843 @default.
- W2188651479 cites W1997926000 @default.
- W2188651479 cites W2003963228 @default.
- W2188651479 cites W2008950328 @default.
- W2188651479 cites W2010072380 @default.
- W2188651479 cites W2011054533 @default.
- W2188651479 cites W2012564902 @default.
- W2188651479 cites W2012935489 @default.
- W2188651479 cites W2013529909 @default.
- W2188651479 cites W2014591096 @default.
- W2188651479 cites W2015852353 @default.
- W2188651479 cites W2015971850 @default.
- W2188651479 cites W2016229941 @default.
- W2188651479 cites W2016560465 @default.
- W2188651479 cites W2016637960 @default.
- W2188651479 cites W2017391549 @default.
- W2188651479 cites W2017909395 @default.
- W2188651479 cites W2019616115 @default.
- W2188651479 cites W2021522589 @default.
- W2188651479 cites W2022084143 @default.
- W2188651479 cites W2026703782 @default.
- W2188651479 cites W2027478328 @default.
- W2188651479 cites W2033719920 @default.
- W2188651479 cites W2033887376 @default.
- W2188651479 cites W2036591225 @default.
- W2188651479 cites W2036931525 @default.
- W2188651479 cites W2038103161 @default.
- W2188651479 cites W2039669179 @default.
- W2188651479 cites W2042214930 @default.
- W2188651479 cites W2045397264 @default.
- W2188651479 cites W2045738784 @default.
- W2188651479 cites W2047247930 @default.
- W2188651479 cites W2050476539 @default.
- W2188651479 cites W2051013472 @default.
- W2188651479 cites W2052904401 @default.
- W2188651479 cites W2055168506 @default.
- W2188651479 cites W2055901230 @default.
- W2188651479 cites W2060476962 @default.
- W2188651479 cites W2061444964 @default.
- W2188651479 cites W2063446370 @default.
- W2188651479 cites W2064100104 @default.
- W2188651479 cites W2066786946 @default.
- W2188651479 cites W2066832729 @default.
- W2188651479 cites W2068472192 @default.
- W2188651479 cites W2075553837 @default.
- W2188651479 cites W2078693180 @default.
- W2188651479 cites W2079953735 @default.
- W2188651479 cites W2080904568 @default.
- W2188651479 cites W2081050014 @default.
- W2188651479 cites W2082057981 @default.
- W2188651479 cites W2082363445 @default.
- W2188651479 cites W2086916172 @default.
- W2188651479 cites W2091622145 @default.
- W2188651479 cites W2093071923 @default.
- W2188651479 cites W2097612780 @default.
- W2188651479 cites W2098587915 @default.
- W2188651479 cites W2100351369 @default.
- W2188651479 cites W2102665979 @default.
- W2188651479 cites W2102995110 @default.
- W2188651479 cites W2103827225 @default.
- W2188651479 cites W2105468266 @default.
- W2188651479 cites W2106378155 @default.