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- W2188665654 abstract "(ie, FLT3 internal tandem duplication [FLT3-ITD], or NPM1 wild type [wt], or both). Among the subset of patients with NPM1wt but without FLT3-ITD, we observed that CEBPA mutations conferred a better prognosis, with the 5-year event-free survival rates for 21 patients with CEBPA mutations of 62% v 13% for 24 patients with CEBPAwt (P .0003). However, the assessment of the subset with FLT3-ITDisdifficultbecauseofthesmallnumberofpatientsharboring both FLT3-ITD and CEBPA mutations in our patient set—there were only eight such patients. 3 When these patients were compared with those with FLT3-ITD and CEBPAwt (n 62), the 5-year eventfree survival rates were 38% and 19%, respectively, but the difference was not statistically significant (P .44). Thus, whereas CEBPA mutations seem to affect favorably the outcome of the patients with molecular high-risk cytogenetically normal acute myeloid leukemia without FLT3-ITD, a larger set of patients harboring FLT3-ITD and CEBPA mutations needs to be analyzed before definitive conclusions as to the prognostic significance of CEBPA mutations in FLT3-ITD‐ positive patients can be drawn." @default.
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- W2188665654 date "2009-01-01" @default.
- W2188665654 modified "2023-09-24" @default.
- W2188665654 title "Resection of Uninvolved Adjacent Organs Can Be Part of Surgery for Retroperitoneal Soft Tissue Sarcoma" @default.
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