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- W2188683820 abstract "Herbal Supplements are vital part of today’s comprehensive health maintenance because of their safety, efficacy and lesser side effects. One of such herb having medicinal importance is Garlic (Allium sativum L., family Liliaceae) which has been used to prevent cardiovascular disorders. Different forms of garlic preparations (powders, oils, Aged Garlic Extract etc.) differ in chemical composition. Present study deals with the formulation of enteric coated oral sustained release garlic tablet which will be most effective on all circulatory disorders as it is a very important system affected in every form of disease. Tablets were formulated by non-aqueous wet granulation method using HPMC, Carbopol, Ethyl cellulose, Xanthan gum as release retarding polymers. The influence of polymer type and concentration on dissolution of tablets and release mechanisms were explained. 2 3 full factorial design was applied to systematically optimize the drug release profile using amount of polymer, binder and diluent as independent variables and release after 12h was selected as dependent variables. The tablets were found to release 85.66% of active constituents in 12h. Drug release mechanism was found to be diffusion controlled. Suitable combination of polymer, binder and diluent provided fairly good regulated release profile. The optimum formulation was chosen and its predicted result found to be in close agreement with experimental findings. A decrease in release kinetics of the drug was observed by increasing the polymer concentration. Sustained release garlic tablets can provide maximum health benefits of fresh, wholesome garlic to the cardiovascular and immune systems all day long without the garlic odor." @default.
- W2188683820 created "2016-06-24" @default.
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- W2188683820 date "2010-01-01" @default.
- W2188683820 modified "2023-09-26" @default.
- W2188683820 title "DESIGN AND EVALUATION OF GARLIC SUSTAINED RELEASE MATRIX TABLETS." @default.
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