Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188693641> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2188693641 endingPage "93" @default.
- W2188693641 startingPage "84" @default.
- W2188693641 abstract "The increasing prevalence and distribution of malaria has been attributed to a number of factors, one of them being the emergence and spread of drug resistant parasites. Efforts are now being directed towards the discovery and development of new chemically diverse anti-malarial agents. The present study reports on the in vitro anti-plasmodial activity of 15 selected medicinal plants used widely by the traditional healers to treat malaria in the North Rift parts of Kenya. The plant extracts were tested for in vitro activity against chloroquin-senitive (D6) strains of plasmodium falciparum parasites. Of the 15 species assayed, 40% showed promising anti-plasmodial activity of IC 50 ≤ 10 µg/ml, while another 40% showed moderate activity of IC 50 between 10 – 50 µg/ml and 20% had weak activity of IC 50 between 50 – 100 µg/ml. These results justify the correlation between traditional uses of the plants with their bioactivity. Synergism between total extract of Atemisia annua and Carissa edulis ware also analyzed using combination ratios of 10:90 to 90:10 respectively against P.falciparum parasites. This led to the identification of anti-malarial combination therapy of methanolic extracts of the two plants with sum of fraction inhibiting concentration (FIC) of 0.74 at 50% combination ratios. These results support a rational rather than random approach to the selection of anti-plasmodial screening candidates, and identify a number of promising plants for further investigation as plant-based anti-malarial agents." @default.
- W2188693641 created "2016-06-24" @default.
- W2188693641 creator A5000918928 @default.
- W2188693641 creator A5021102215 @default.
- W2188693641 creator A5084155109 @default.
- W2188693641 date "2012-09-01" @default.
- W2188693641 modified "2023-09-26" @default.
- W2188693641 title "Anti-Plasmodial Activity of Some Medicinal Plants Used for Treatment of Malaria and Synergism of Methanolic Extracts of Carissa Edulis and Artemisia Annua" @default.
- W2188693641 cites W1791249054 @default.
- W2188693641 cites W1825469542 @default.
- W2188693641 cites W1853736668 @default.
- W2188693641 cites W1969503178 @default.
- W2188693641 cites W2047272477 @default.
- W2188693641 cites W2093993602 @default.
- W2188693641 cites W2098923921 @default.
- W2188693641 cites W2110152985 @default.
- W2188693641 cites W2112191861 @default.
- W2188693641 cites W2130853973 @default.
- W2188693641 cites W2155701533 @default.
- W2188693641 cites W2158323574 @default.
- W2188693641 cites W2164094084 @default.
- W2188693641 cites W2469904498 @default.
- W2188693641 hasPublicationYear "2012" @default.
- W2188693641 type Work @default.
- W2188693641 sameAs 2188693641 @default.
- W2188693641 citedByCount "0" @default.
- W2188693641 crossrefType "journal-article" @default.
- W2188693641 hasAuthorship W2188693641A5000918928 @default.
- W2188693641 hasAuthorship W2188693641A5021102215 @default.
- W2188693641 hasAuthorship W2188693641A5084155109 @default.
- W2188693641 hasConcept C203014093 @default.
- W2188693641 hasConcept C2776120307 @default.
- W2188693641 hasConcept C2777389444 @default.
- W2188693641 hasConcept C2778048844 @default.
- W2188693641 hasConcept C2778371730 @default.
- W2188693641 hasConcept C2779158651 @default.
- W2188693641 hasConcept C2779691961 @default.
- W2188693641 hasConcept C2908859342 @default.
- W2188693641 hasConcept C556039675 @default.
- W2188693641 hasConcept C59822182 @default.
- W2188693641 hasConcept C71924100 @default.
- W2188693641 hasConcept C86803240 @default.
- W2188693641 hasConceptScore W2188693641C203014093 @default.
- W2188693641 hasConceptScore W2188693641C2776120307 @default.
- W2188693641 hasConceptScore W2188693641C2777389444 @default.
- W2188693641 hasConceptScore W2188693641C2778048844 @default.
- W2188693641 hasConceptScore W2188693641C2778371730 @default.
- W2188693641 hasConceptScore W2188693641C2779158651 @default.
- W2188693641 hasConceptScore W2188693641C2779691961 @default.
- W2188693641 hasConceptScore W2188693641C2908859342 @default.
- W2188693641 hasConceptScore W2188693641C556039675 @default.
- W2188693641 hasConceptScore W2188693641C59822182 @default.
- W2188693641 hasConceptScore W2188693641C71924100 @default.
- W2188693641 hasConceptScore W2188693641C86803240 @default.
- W2188693641 hasIssue "1" @default.
- W2188693641 hasLocation W21886936411 @default.
- W2188693641 hasOpenAccess W2188693641 @default.
- W2188693641 hasPrimaryLocation W21886936411 @default.
- W2188693641 hasVolume "1" @default.
- W2188693641 isParatext "false" @default.
- W2188693641 isRetracted "false" @default.
- W2188693641 magId "2188693641" @default.
- W2188693641 workType "article" @default.