FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188719005> ?p ?o ?g. }

• W2188719005 endingPage "115" @default.
• W2188719005 startingPage "107" @default.
• W2188719005 abstract "In vivo studies have shown abnormalities in cholesterol and bile acid metabolism in primary hyperlipoproteinemia (HLP). The aim of the present investigation was to determine if the increased production of cholesterol in HLP type IV can be attributed to a correspondingly high level of the hepatic 3-hydroxy-3-methylglutaryl (HMG) CoA reductase activity and if the low cholic acid: chenodeoxycholic acid synthesis ratio in HLP type II is due to some hydroxylase deficiency. Liver biopsies from 26 normolipidemic and 25 hyperlipidemic (10 type IIa, 6 type IIb, and 9 type IV) patients undergoing elective cholecystectomy were assayed for HMG CoA reductase activity, 12 alpha-hydroxylase activity, and 25-hydroxylase activity. The HMG CoA reductase activity was normal in HLP type IIa and type IIb and was increased about twice HLP type IV (P less than 0.001). The 12 alpha- and 25-hydroxylase activities were normal in all groups of patients. The results are compatible with a normal cholesterol synthesis in the liver in HLP type II. A reduced 12 alpha- or 25-hydroxylase activity cannot explain the low production of cholic acid relative to chenodeoxycholic acid in this type of HLP. The elevated HMG CoA reductase activity found in the liver of type IV patients may, however, be part of the explanation for the elevated synthesis of cholesterol often seen in these patients." @default.
• W2188719005 created "2016-06-24" @default.
• W2188719005 creator A5050942061 @default.
• W2188719005 creator A5055691394 @default.
• W2188719005 creator A5072704585 @default.
• W2188719005 creator A5075350866 @default.
• W2188719005 creator A5087634388 @default.
• W2188719005 date "1979-01-01" @default.
• W2188719005 modified "2023-09-25" @default.
• W2188719005 title "Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones." @default.
• W2188719005 cites W13351788 @default.
• W2188719005 cites W1551478473 @default.
• W2188719005 cites W1585443857 @default.
• W2188719005 cites W1775749144 @default.
• W2188719005 cites W1939209412 @default.
• W2188719005 cites W1966442116 @default.
• W2188719005 cites W1968375829 @default.
• W2188719005 cites W1973517605 @default.
• W2188719005 cites W1977082616 @default.
• W2188719005 cites W1978366022 @default.
• W2188719005 cites W1989381716 @default.
• W2188719005 cites W1989728080 @default.
• W2188719005 cites W1994820799 @default.
• W2188719005 cites W2001234172 @default.
• W2188719005 cites W2002044281 @default.
• W2188719005 cites W2003801590 @default.
• W2188719005 cites W2004059658 @default.
• W2188719005 cites W2019365522 @default.
• W2188719005 cites W2030010306 @default.
• W2188719005 cites W2030959579 @default.
• W2188719005 cites W2041307432 @default.
• W2188719005 cites W2044306097 @default.
• W2188719005 cites W2048385224 @default.
• W2188719005 cites W2050960751 @default.
• W2188719005 cites W2054979785 @default.
• W2188719005 cites W2056474881 @default.
• W2188719005 cites W2060057936 @default.
• W2188719005 cites W2081046044 @default.
• W2188719005 cites W2090113697 @default.
• W2188719005 cites W2091015159 @default.
• W2188719005 cites W2137848503 @default.
• W2188719005 cites W2142802148 @default.
• W2188719005 cites W2150468907 @default.
• W2188719005 cites W2168017436 @default.
• W2188719005 cites W2185667574 @default.
• W2188719005 cites W2186454374 @default.
• W2188719005 cites W2188244205 @default.
• W2188719005 cites W2310361929 @default.
• W2188719005 cites W2329097816 @default.
• W2188719005 cites W2413080196 @default.
• W2188719005 cites W2419229014 @default.
• W2188719005 cites W2465382919 @default.
• W2188719005 cites W2615411536 @default.
• W2188719005 cites W2928024704 @default.
• W2188719005 cites W4299621223 @default.
• W2188719005 doi "https://doi.org/10.1016/s0022-2275(20)40656-x" @default.
• W2188719005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/374662" @default.
• W2188719005 hasPublicationYear "1979" @default.
• W2188719005 type Work @default.
• W2188719005 sameAs 2188719005 @default.
• W2188719005 citedByCount "37" @default.
• W2188719005 countsByYear W21887190052021 @default.
• W2188719005 crossrefType "journal-article" @default.
• W2188719005 hasAuthorship W2188719005A5050942061 @default.
• W2188719005 hasAuthorship W2188719005A5055691394 @default.
• W2188719005 hasAuthorship W2188719005A5072704585 @default.
• W2188719005 hasAuthorship W2188719005A5075350866 @default.
• W2188719005 hasAuthorship W2188719005A5087634388 @default.
• W2188719005 hasBestOaLocation W21887190051 @default.
• W2188719005 hasConcept C104950815 @default.
• W2188719005 hasConcept C126322002 @default.
• W2188719005 hasConcept C134018914 @default.
• W2188719005 hasConcept C134651460 @default.
• W2188719005 hasConcept C181199279 @default.
• W2188719005 hasConcept C185592680 @default.
• W2188719005 hasConcept C2775900799 @default.
• W2188719005 hasConcept C2777320049 @default.
• W2188719005 hasConcept C2778163477 @default.
• W2188719005 hasConcept C2779388726 @default.
• W2188719005 hasConcept C2779399885 @default.
• W2188719005 hasConcept C2780965833 @default.
• W2188719005 hasConcept C2781089062 @default.
• W2188719005 hasConcept C55493867 @default.
• W2188719005 hasConcept C62231903 @default.
• W2188719005 hasConcept C71924100 @default.
• W2188719005 hasConcept C89673097 @default.
• W2188719005 hasConceptScore W2188719005C104950815 @default.
• W2188719005 hasConceptScore W2188719005C126322002 @default.
• W2188719005 hasConceptScore W2188719005C134018914 @default.
• W2188719005 hasConceptScore W2188719005C134651460 @default.
• W2188719005 hasConceptScore W2188719005C181199279 @default.
• W2188719005 hasConceptScore W2188719005C185592680 @default.
• W2188719005 hasConceptScore W2188719005C2775900799 @default.
• W2188719005 hasConceptScore W2188719005C2777320049 @default.
• W2188719005 hasConceptScore W2188719005C2778163477 @default.
• W2188719005 hasConceptScore W2188719005C2779388726 @default.
• W2188719005 hasConceptScore W2188719005C2779399885 @default.
• W2188719005 hasConceptScore W2188719005C2780965833 @default.

• next