Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188736070> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2188736070 endingPage "176" @default.
- W2188736070 startingPage "170" @default.
- W2188736070 abstract "Correct positioning and differentiation of neurons during brain development is a key precondition for proper function. Focal cortical dysplasias (FCDs) are increasingly recognized as causes of therapy refractory epilepsies. Neuropathological analyses of respective surgical specimens from neurosurgery for seizure control often reveal aberrant cortical architecture and/or aberrantly shaped neurons in FCDs. However, the molecular pathogenesis particularly of FCDs with aberrant lamination (so-called FCD type I) is largely unresolved. Lipoproteins and particularly low-density lipoprotein receptor-related protein 12 (LRP12) are involved in brain development. Here, we have examined a potential role of LRP12 in the pathogenesis of FCDs. In vitro knockdown of LRP12 in primary neurons results in impaired neuronal arborization. In vivo ablation of LRP12 by intraventricularly in utero electroporated shRNAs elicits cortical maldevelopment, i.e. aberrant lamination by malpositioning of upper cortical layer neurons. Subsequent epilepsy phenotyping revealed pentylenetetrazol (PTZ)-induced seizures to be aggravated in cortical LRP12-silenced mice. Our data demonstrates IUE mediated cortical gene silencing as an excellent approach to study the role of distinct molecules for epilepsy associated focal brain lesions and suggests LRP12 and lipoprotein homeostasis as potential molecular target structures for the emergence of epilepsy-associated FCDs." @default.
- W2188736070 created "2016-06-24" @default.
- W2188736070 creator A5003615920 @default.
- W2188736070 creator A5009852039 @default.
- W2188736070 creator A5019226669 @default.
- W2188736070 creator A5036952503 @default.
- W2188736070 creator A5049539458 @default.
- W2188736070 creator A5072488640 @default.
- W2188736070 date "2016-02-01" @default.
- W2188736070 modified "2023-10-13" @default.
- W2188736070 title "LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization" @default.
- W2188736070 cites W1967982621 @default.
- W2188736070 cites W1984764912 @default.
- W2188736070 cites W1987182404 @default.
- W2188736070 cites W1988635753 @default.
- W2188736070 cites W1999391469 @default.
- W2188736070 cites W2015986408 @default.
- W2188736070 cites W2032166622 @default.
- W2188736070 cites W2055635898 @default.
- W2188736070 cites W2077692264 @default.
- W2188736070 cites W2088313847 @default.
- W2188736070 cites W2094167769 @default.
- W2188736070 cites W2102561151 @default.
- W2188736070 cites W2105727230 @default.
- W2188736070 cites W2109232641 @default.
- W2188736070 cites W2129975913 @default.
- W2188736070 cites W2143203730 @default.
- W2188736070 cites W2144586440 @default.
- W2188736070 cites W2150293957 @default.
- W2188736070 cites W2156198928 @default.
- W2188736070 cites W2325289632 @default.
- W2188736070 doi "https://doi.org/10.1016/j.nbd.2015.11.021" @default.
- W2188736070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26639854" @default.
- W2188736070 hasPublicationYear "2016" @default.
- W2188736070 type Work @default.
- W2188736070 sameAs 2188736070 @default.
- W2188736070 citedByCount "11" @default.
- W2188736070 countsByYear W21887360702016 @default.
- W2188736070 countsByYear W21887360702017 @default.
- W2188736070 countsByYear W21887360702018 @default.
- W2188736070 countsByYear W21887360702020 @default.
- W2188736070 countsByYear W21887360702021 @default.
- W2188736070 countsByYear W21887360702022 @default.
- W2188736070 countsByYear W21887360702023 @default.
- W2188736070 crossrefType "journal-article" @default.
- W2188736070 hasAuthorship W2188736070A5003615920 @default.
- W2188736070 hasAuthorship W2188736070A5009852039 @default.
- W2188736070 hasAuthorship W2188736070A5019226669 @default.
- W2188736070 hasAuthorship W2188736070A5036952503 @default.
- W2188736070 hasAuthorship W2188736070A5049539458 @default.
- W2188736070 hasAuthorship W2188736070A5072488640 @default.
- W2188736070 hasConcept C104317684 @default.
- W2188736070 hasConcept C119056186 @default.
- W2188736070 hasConcept C169760540 @default.
- W2188736070 hasConcept C2777348757 @default.
- W2188736070 hasConcept C2778186239 @default.
- W2188736070 hasConcept C2781041448 @default.
- W2188736070 hasConcept C55493867 @default.
- W2188736070 hasConcept C57236427 @default.
- W2188736070 hasConcept C71924100 @default.
- W2188736070 hasConcept C86803240 @default.
- W2188736070 hasConceptScore W2188736070C104317684 @default.
- W2188736070 hasConceptScore W2188736070C119056186 @default.
- W2188736070 hasConceptScore W2188736070C169760540 @default.
- W2188736070 hasConceptScore W2188736070C2777348757 @default.
- W2188736070 hasConceptScore W2188736070C2778186239 @default.
- W2188736070 hasConceptScore W2188736070C2781041448 @default.
- W2188736070 hasConceptScore W2188736070C55493867 @default.
- W2188736070 hasConceptScore W2188736070C57236427 @default.
- W2188736070 hasConceptScore W2188736070C71924100 @default.
- W2188736070 hasConceptScore W2188736070C86803240 @default.
- W2188736070 hasLocation W21887360701 @default.
- W2188736070 hasLocation W21887360702 @default.
- W2188736070 hasOpenAccess W2188736070 @default.
- W2188736070 hasPrimaryLocation W21887360701 @default.
- W2188736070 hasRelatedWork W1973745785 @default.
- W2188736070 hasRelatedWork W1995679204 @default.
- W2188736070 hasRelatedWork W2014281284 @default.
- W2188736070 hasRelatedWork W2033730667 @default.
- W2188736070 hasRelatedWork W2100134532 @default.
- W2188736070 hasRelatedWork W2159894899 @default.
- W2188736070 hasRelatedWork W2409827884 @default.
- W2188736070 hasRelatedWork W2595861884 @default.
- W2188736070 hasRelatedWork W4291595125 @default.
- W2188736070 hasRelatedWork W2594205478 @default.
- W2188736070 hasVolume "86" @default.
- W2188736070 isParatext "false" @default.
- W2188736070 isRetracted "false" @default.
- W2188736070 magId "2188736070" @default.
- W2188736070 workType "article" @default.