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• W2188742158 abstract "<h3>Objective:</h3> For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms. <h3>Methods:</h3> We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-free populations are associated overall when combined with stroke populations. <h3>Results:</h3> There were no associations at genome-wide significance with WMHV in stroke patients. All previously reported genome-wide significant associations with WMHV in community populations shared direction of effect in stroke patients. In a meta-analysis of the genome-wide significant and suggestive loci (<i>p</i> < 5 × 10⁻⁶) from community populations (15 single nucleotide polymorphisms in total) and from stroke patients, 6 independent loci were associated with WMHV in both populations. Four of these are novel associations at the genome-wide level (rs72934505 [<i>NBEAL1</i>], <i>p</i> = 2.2 × 10⁻⁸; rs941898 [<i>EVL</i>], <i>p</i> = 4.0 × 10⁻⁸; rs962888 [<i>C1QL1</i>], <i>p</i> = 1.1 × 10⁻⁸; rs9515201 [<i>COL4A2</i>], <i>p</i> = 6.9 × 10⁻⁹). <h3>Conclusions:</h3> Genetic associations with WMHV are shared in otherwise healthy individuals and patients with stroke, indicating common genetic susceptibility in cerebral small vessel disease." @default.
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• W2188742158 date "2015-12-16" @default.
• W2188742158 modified "2023-09-25" @default.
• W2188742158 title "Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke" @default.
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• W2188742158 doi "https://doi.org/10.1212/wnl.0000000000002263" @default.
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