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- W2188766196 abstract "Summary Current treatment of Parkinson's disease is based on Dopamine replacement therapy but this leads to long-term complications. Aim of present study was to examine the effect of alcoholic extract of Mucuna pruriens (MPE) on the induction or expression of context dependent augmentation (sensitization) of catalepsy in rats, which develops with repeated administration of haloperidol. Catalepsy induced by haloperidol (0.1-0.5 mg/kg, i.p.) was assessed by bar test periodically upto 3 h in rats. Haloperidol (0.2 mg/kg i.p) produced catalepsy, which increased day by day (sensitization of catalepsy). L-DOPA ((0.5. mg/kg, i.p.) showed antagonism of HAL catalepsy upto 5 days and sensitization was shown day-6 onwards. MPE (200 mg/kg, oral) exhibits antagonism of HAL induced catalepsy after day-2 onwards and persisted even after HAL challenge on day-8. combined treatment of L-DOPA with MPE showed significant antagonism of catalepsy from day-2 onwards which reached to maximum on day-3 and persisted till day-6 and sustained even after HAL challenge on day8. In conclusion, MPE appears to be beneficial adjuvant treatment with L-DOPA in the management of Parkinson’s disease." @default.
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- W2188766196 date "2006-01-01" @default.
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- W2188766196 title "EFFECT OF MUCUNA PRURIENS ON HALOPERIDOL INDUCED SENSITIZATION OF CATALEPSY" @default.
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