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• W2188766997 abstract "Purpose. This study aimed to determine the dynamic changes of NF-κB-related microRNAs (miRNAs) and cytokines over the course of experimental autoimmune anterior uveitis (EAAU) and elucidate the possible immunopathogenesis. Materials and Methods. Uveitis was induced in Lewis rats using bovine melanin-associated antigen. The inflammatory activity of the anterior chamber was clinically scored, and leukocytes in the aqueous humor were quantified. RNA was extracted from the iris/ciliary bodies and popliteal lymph nodes to reveal the dynamic changes of eight target miRNAs (miR-155-5p, miR-146a-5p, miR-182-5p, miR-183-5p, miR-147b, miR-21-5p, miR-9-3p, and miR-223-3p) and six cytokine mRNAs (IFN-γ, IL-17, IL-12A, IL-1β, IL-6, and IL-10). In situ hybridization of miRNA and enzyme-linked immunosorbent assay quantification of cytokines were performed to confirm the results. Results. Disease activity and leukocyte quantification were maximum at day 15 after immunization. The profiling of miRNA revealed downregulation of miR-146a-5p, miR-155-5p, miR-223-3p, and miR-147b and upregulation of miR-182-5p, miR-183-5p, and miR-9-3p. Cytokine analysis revealed IFN-γ, IL-17, IL-12A, IL-1β, and IL-6 overexpression, with IL-10 downregulation. Conclusions. Dynamic changes of miRNAs were observed over the course of EAAU. By initiating NF-κB signaling, the expressions of downstream cytokines and effector cells from the Th17 and Th1 lineages were sequentially activated, contributing to the disease." @default.
• W2188766997 created "2016-06-24" @default.
• W2188766997 creator A5025657344 @default.
• W2188766997 creator A5032344278 @default.
• W2188766997 creator A5033367618 @default.
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• W2188766997 date "2015-01-01" @default.
• W2188766997 modified "2023-09-22" @default.
• W2188766997 title "Expression of MicroRNAs in the Eyes of Lewis Rats with Experimental Autoimmune Anterior Uveitis" @default.
• W2188766997 cites W1514234789 @default.
• W2188766997 cites W1544914507 @default.
• W2188766997 cites W1546278502 @default.
• W2188766997 cites W1618749171 @default.
• W2188766997 cites W1866549238 @default.
• W2188766997 cites W1950453196 @default.
• W2188766997 cites W1964499676 @default.
• W2188766997 cites W1966054625 @default.
• W2188766997 cites W1966338717 @default.
• W2188766997 cites W1968155401 @default.
• W2188766997 cites W1970263037 @default.
• W2188766997 cites W1970556324 @default.
• W2188766997 cites W1973416829 @default.
• W2188766997 cites W1973961185 @default.
• W2188766997 cites W1981651463 @default.
• W2188766997 cites W1986627716 @default.
• W2188766997 cites W1987955922 @default.
• W2188766997 cites W1988318286 @default.
• W2188766997 cites W1996460626 @default.
• W2188766997 cites W1996462805 @default.
• W2188766997 cites W2000582201 @default.
• W2188766997 cites W2009028704 @default.
• W2188766997 cites W2010682101 @default.
• W2188766997 cites W2014869583 @default.
• W2188766997 cites W2014946489 @default.
• W2188766997 cites W2016924387 @default.
• W2188766997 cites W2018436109 @default.
• W2188766997 cites W2023812320 @default.
• W2188766997 cites W2026675786 @default.
• W2188766997 cites W2028143266 @default.
• W2188766997 cites W2028994878 @default.
• W2188766997 cites W2036091291 @default.
• W2188766997 cites W2037269612 @default.
• W2188766997 cites W2041717813 @default.
• W2188766997 cites W2041820432 @default.
• W2188766997 cites W2048519588 @default.
• W2188766997 cites W2050155729 @default.
• W2188766997 cites W2052704975 @default.
• W2188766997 cites W2059141867 @default.
• W2188766997 cites W2059695215 @default.
• W2188766997 cites W2061217789 @default.
• W2188766997 cites W2062903634 @default.
• W2188766997 cites W2066743612 @default.
• W2188766997 cites W2067530408 @default.
• W2188766997 cites W2071341064 @default.
• W2188766997 cites W2072628057 @default.
• W2188766997 cites W2075860675 @default.
• W2188766997 cites W2079851414 @default.
• W2188766997 cites W2083278536 @default.
• W2188766997 cites W2085187432 @default.
• W2188766997 cites W2091026695 @default.
• W2188766997 cites W2091174195 @default.
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• W2188766997 cites W2104751993 @default.
• W2188766997 cites W2107393091 @default.
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• W2188766997 cites W2116779385 @default.
• W2188766997 cites W2124756133 @default.
• W2188766997 cites W2125929767 @default.
• W2188766997 cites W2133571578 @default.
• W2188766997 cites W2134185120 @default.
• W2188766997 cites W2137770333 @default.
• W2188766997 cites W2139499737 @default.
• W2188766997 cites W2161021519 @default.
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• W2188766997 doi "https://doi.org/10.1155/2015/457835" @default.
• W2188766997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4680116" @default.
• W2188766997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26713004" @default.
• W2188766997 hasPublicationYear "2015" @default.
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