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- W2188777735 abstract "Due to the widespread increase in the number of subjects suffering from diabetes, our understanding of the principles governing the formation and function of this organ need to be greatly improved. Although in vitro generation of insulin-secreting cells from embryonic stem cells, induced-pluripotent stem cells and adult stem/progenitor-like cells has been reported, most of these cells are functionally immature and show poor glucose-responsive insulin secretion compared to that of native pancreatic b-cells. The recent evidence that cells in the adult pancreas exhibit more plasticity than previously recognized has opened up new areas of research, such as cellular reprogramming and in vivo β-cell regeneration. Increasing the understanding and finding the right strategies to generate functional b- cells or a whole organ in vivo would not only bring enormous benefits to type I diabetes patients but could also constitute a promising approach to treating type II diabetes as well as type I diabetes in paediatric patients where islet transplantation, even with its substantially improved outcome in recent years, is still not indicated." @default.
- W2188777735 created "2016-06-24" @default.
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- W2188777735 date "2013-01-01" @default.
- W2188777735 modified "2023-09-26" @default.
- W2188777735 title "Models of Regeneration of Beta Cells in Vivo" @default.
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