Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188781652> ?p ?o ?g. }
- W2188781652 abstract "Oral administration of different dosage forms is the most commonly used method due to flexibility in design of dosage form and high patient acceptance, but the gastrointestinal tract presents several formidable barriers to drug delivery. In oral colon-specific drug delivery system, colon has a large amount of lymphoma tissue (facilitates direct absorption in to the blood), negligible brush boarder membrane activity, and much less pancreatic enzymatic activity as compared with the small intestine. Colon-specific drug delivery has gained increased importance not just for the delivery of the drugs for treatment of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides. Different approaches are designed based on prodrug formulation, pH-sensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes for colon targeting. The delivery of drugs to the colon has a number of therapeutic implications in the field of drug delivery. In the recent times, the colon specific delivery systems are also gaining importance not only for local drug delivery of drugs but also for the systemic delivery of protein and peptide drugs. This review updated the research on different approaches for formulation and evaluation of colon-specific drug delivery systems (CDDS). Reduce the dosage size and frequency, enhance drugs solubility, permeability and bioavailability, accumulation of the particulate carrier system in the desired site may be get by CDDS." @default.
- W2188781652 created "2016-06-24" @default.
- W2188781652 creator A5001251863 @default.
- W2188781652 creator A5065492623 @default.
- W2188781652 date "2011-01-01" @default.
- W2188781652 modified "2023-09-24" @default.
- W2188781652 title "THE DESIGN OF COLON-SPECIFIC DRUG DELIVERY SYSTEM AND DIFFERENT APPROACHES TO TREAT COLON DISEASE Review Article" @default.
- W2188781652 cites W1672660987 @default.
- W2188781652 cites W1969289712 @default.
- W2188781652 cites W1970344096 @default.
- W2188781652 cites W1972872822 @default.
- W2188781652 cites W1975269797 @default.
- W2188781652 cites W1975890300 @default.
- W2188781652 cites W1976191247 @default.
- W2188781652 cites W1976467447 @default.
- W2188781652 cites W1985457023 @default.
- W2188781652 cites W1985823814 @default.
- W2188781652 cites W1985981088 @default.
- W2188781652 cites W1988557829 @default.
- W2188781652 cites W1991092566 @default.
- W2188781652 cites W1995263937 @default.
- W2188781652 cites W2001925592 @default.
- W2188781652 cites W2006554458 @default.
- W2188781652 cites W2009008364 @default.
- W2188781652 cites W2026605096 @default.
- W2188781652 cites W2028882729 @default.
- W2188781652 cites W2029103483 @default.
- W2188781652 cites W2032200459 @default.
- W2188781652 cites W2036960118 @default.
- W2188781652 cites W2040993863 @default.
- W2188781652 cites W2043218065 @default.
- W2188781652 cites W2063196771 @default.
- W2188781652 cites W2069417660 @default.
- W2188781652 cites W2078455840 @default.
- W2188781652 cites W2080492283 @default.
- W2188781652 cites W2085444179 @default.
- W2188781652 cites W2087785772 @default.
- W2188781652 cites W2089527692 @default.
- W2188781652 cites W2091255504 @default.
- W2188781652 cites W2104731190 @default.
- W2188781652 cites W2107142248 @default.
- W2188781652 cites W2119104570 @default.
- W2188781652 cites W2120173244 @default.
- W2188781652 cites W2129907661 @default.
- W2188781652 cites W2137994868 @default.
- W2188781652 cites W2141000131 @default.
- W2188781652 cites W2144964291 @default.
- W2188781652 cites W2145265188 @default.
- W2188781652 cites W2147828308 @default.
- W2188781652 cites W2149487795 @default.
- W2188781652 cites W2149507744 @default.
- W2188781652 cites W2161899697 @default.
- W2188781652 cites W2340993037 @default.
- W2188781652 cites W872695815 @default.
- W2188781652 cites W2301699958 @default.
- W2188781652 hasPublicationYear "2011" @default.
- W2188781652 type Work @default.
- W2188781652 sameAs 2188781652 @default.
- W2188781652 citedByCount "4" @default.
- W2188781652 countsByYear W21887816522012 @default.
- W2188781652 countsByYear W21887816522014 @default.
- W2188781652 crossrefType "journal-article" @default.
- W2188781652 hasAuthorship W2188781652A5001251863 @default.
- W2188781652 hasAuthorship W2188781652A5065492623 @default.
- W2188781652 hasConcept C108215921 @default.
- W2188781652 hasConcept C112705442 @default.
- W2188781652 hasConcept C126511603 @default.
- W2188781652 hasConcept C13245373 @default.
- W2188781652 hasConcept C178790620 @default.
- W2188781652 hasConcept C181389837 @default.
- W2188781652 hasConcept C185592680 @default.
- W2188781652 hasConcept C19831878 @default.
- W2188781652 hasConcept C2779820397 @default.
- W2188781652 hasConcept C2780035454 @default.
- W2188781652 hasConcept C71924100 @default.
- W2188781652 hasConcept C77281830 @default.
- W2188781652 hasConcept C98274493 @default.
- W2188781652 hasConceptScore W2188781652C108215921 @default.
- W2188781652 hasConceptScore W2188781652C112705442 @default.
- W2188781652 hasConceptScore W2188781652C126511603 @default.
- W2188781652 hasConceptScore W2188781652C13245373 @default.
- W2188781652 hasConceptScore W2188781652C178790620 @default.
- W2188781652 hasConceptScore W2188781652C181389837 @default.
- W2188781652 hasConceptScore W2188781652C185592680 @default.
- W2188781652 hasConceptScore W2188781652C19831878 @default.
- W2188781652 hasConceptScore W2188781652C2779820397 @default.
- W2188781652 hasConceptScore W2188781652C2780035454 @default.
- W2188781652 hasConceptScore W2188781652C71924100 @default.
- W2188781652 hasConceptScore W2188781652C77281830 @default.
- W2188781652 hasConceptScore W2188781652C98274493 @default.
- W2188781652 hasLocation W21887816521 @default.
- W2188781652 hasOpenAccess W2188781652 @default.
- W2188781652 hasPrimaryLocation W21887816521 @default.
- W2188781652 hasRelatedWork W1980600720 @default.
- W2188781652 hasRelatedWork W2173745151 @default.
- W2188781652 hasRelatedWork W2183110510 @default.
- W2188781652 hasRelatedWork W2187748577 @default.
- W2188781652 hasRelatedWork W2188777753 @default.
- W2188781652 hasRelatedWork W2189444254 @default.
- W2188781652 hasRelatedWork W2289550236 @default.