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- W2188781677 abstract "The opportunistic human pathogen Pseudomonas aeruginosa regulates production of numerous virulence factors via the action of two separate but coordinated quorum sensing systems, las and rhl. These systems control the transcription of genes in response to population density through the intercellular signals N-(3oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) and N-(butanoyl)-Lhomoserine lactone (C4-HSL). Also plays a significant role in the transcription of multiple P. aeruginosa virulence genes. A total of 60 clinical isolates of gram negative bacteria primarily identified as P. aeruginosa were obtained from different teaching hospitals in Baghdad, the isolates were confirmed as P. aeruginosa by PCR which was performed by housekeeping gene (rpsl gene) and also screened of four quorum sensing genes (rhlR, rhlI, lasR, lasI) and linked with four virulence factor (exoU, exoS, PilB, protease IV). Sequence analyses of these isolates showed that the lasR, lasI, rhlR and rhlI genes had mutations. The combination of these mutations probably explains virulence factor deficiencies. Results of this study suggest that QS (quorum sensing) deficient clinical isolates occur and are still capable of causing clinical infections in humans." @default.
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- W2188781677 date "2014-01-01" @default.
- W2188781677 modified "2023-09-27" @default.
- W2188781677 title "Prevalence study of quorum sensing groups among clinical isolates of Pseudomonas aeruginosa" @default.
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