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- W2188791252 abstract "Summary research circadian variation of antinociceptive effect of adenosine and two A1 adenosine receptor agonists, (R) N6�phenylisopropyl adenosine ( RPIA ) and 2 -chloroadenosine (2�CAdo), and pain were studied in male mice that housed under control light phase for two weeks. Circadian variation of pain was performed on intact mice by using hot plate test. Doses of 40, 2 and 0.6 mg/kg of adenosine, 2�ClAdo a RPIA, respectively were injected intraperitoneallythree separated groups of six male mice at six hour intervals (09:00, 15:00, 21:00, and 03:00). The control group received normal saline. The result of circadian rhythm of pain showed that the minimum nociceptive effect was observed in dark phase in mice and it was time dependent. The peak of antinociceptive effect of adenosine was in dark phase (21:00 P.M.) at 0.5 h after of injection. The results of 2�ClAdo indicated that maximum of antinociceptive ef fect was in dark phase and results of RPIA exhibited th at peak of antinociceptive activity was in light phase. This study indicated that the pattern of pain in male mice has circadian variation. The antinociceptive effect of adenosine and its two agonists was time dependent. This circadian variation in antinociceptive activity may be important in the administration of these agents." @default.
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- W2188791252 date "2009-01-01" @default.
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- W2188791252 title "Circadian variation of antinociceptive effect of adenosine and adenosine A1 receptor agonists, N6-phenylisopropyl adenosine and 2 chloroadenosine, in mice" @default.
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