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• W2188795471 abstract "Systemic inflammation associated with chronic obstructive pulmonary disease (COPD) is a risk factor for the development of cardiovascular events. The aim of the present study performed in Guinea pigs chronically exposed to cigarette smoke was to assess the reactivity of rings of pulmonary artery and thoracic aorta isolated in organ bath. Twenty animals were randomly assigned to a control group (n = 10) and another one passively exposed to cigarette smoke for 12 weeks (n = 10). At the end of cigarette smoke exposure period significant decrease of vasodilator endothelial-dependent response to acetylcholine was found both in pulmonary artery (Emax% = 4.53 ± 3.09 vs. 19.28, p < 0.0001; EC50 –Log[M] = 6.45 ± 0.24 vs. 5.42 ± 2.24, p < 0.0001), and thoracic aorta (Emax% = 10.53 ± 5.69 vs. 19.28; p < 0.001, EC50 –Log[M] = 6.84 ± 1.72 vs. 5.06 ± 1.02, p < 0.001), whereas the vasodilator endothelial-independent response to sodium nitroprusside was not changed. The alteration of vasodilator endothelial-dependent response was associated with significant inflammatory changes in lungs and vascular walls. In conclusion, the experimental model we propose has proved viable for showing the systemic inflammatory response induced by passive exposure of guinea pigs to cigarette smoke." @default.
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• W2188795471 date "2008-01-01" @default.
• W2188795471 modified "2023-09-27" @default.
• W2188795471 title "PASSIVE EXPOSURE OF GUINEA PIGS TO CIGARETTE SMOKE INDUCES A SYSTEMIC ENDOTHELIAL DYSFUNCTION" @default.
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