FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188796504> ?p ?o ?g. }

• W2188796504 endingPage "22" @default.
• W2188796504 startingPage "1817" @default.
• W2188796504 abstract "Statins have been used successfully in the treatment of hypercholesterinaemia. Moreover, in vitro studies have shown that statins can trigger apoptosis in a variety of tumor cell lines. In the present study we analysed the effect of mevastatin--a novel inhibitor of HMG-COA reductase, the rate-limiting enzyme of the mevalonate pathway--on U266 human myeloma cells. Apoptosis induced by mevastatin was associated with increased caspase activity and depolarisation of the mitochondrial membrane. Expression of Bcl-2 mRNA and protein was down-regulated, with no change in Bax or Bcl-XL protein production. The mitochondrial program was supported by caspase-8 and cleaved-Bid activity. None of the antibodies neutralizing the death-ligand/death-receptor pathway--TRAIL-R2Fc, anti-TNF-alpha, anti-FASL(NOK-1)--influenced the mevastatin-induced apoptosis. Mevastatin also stimulated shedding of syndecan-1 from the surface of myeloma cells. The apoptosis inducing effect of mevastatin could be considered as a potential participant in a complex antitumor protocol." @default.
• W2188796504 created "2016-06-24" @default.
• W2188796504 creator A5007028954 @default.
• W2188796504 creator A5012080747 @default.
• W2188796504 creator A5040336064 @default.
• W2188796504 creator A5057056068 @default.
• W2188796504 creator A5059536847 @default.
• W2188796504 creator A5061387783 @default.
• W2188796504 creator A5091224882 @default.
• W2188796504 date "2004-07-28" @default.
• W2188796504 modified "2023-10-12" @default.
• W2188796504 title "Mevastatin-induced apoptosis and growth suppression in U266 myeloma cells." @default.
• W2188796504 cites W12110721 @default.
• W2188796504 cites W146999070 @default.
• W2188796504 cites W1748388485 @default.
• W2188796504 cites W1841146742 @default.
• W2188796504 cites W189370476 @default.
• W2188796504 cites W1991787503 @default.
• W2188796504 cites W1991865867 @default.
• W2188796504 cites W2013180434 @default.
• W2188796504 cites W2026048257 @default.
• W2188796504 cites W2035269164 @default.
• W2188796504 cites W2049659810 @default.
• W2188796504 cites W2054120144 @default.
• W2188796504 cites W2058689898 @default.
• W2188796504 cites W2078003307 @default.
• W2188796504 cites W2078603028 @default.
• W2188796504 cites W2079430799 @default.
• W2188796504 cites W2113999599 @default.
• W2188796504 cites W2117046467 @default.
• W2188796504 cites W2147357406 @default.
• W2188796504 cites W2150484958 @default.
• W2188796504 cites W2151528266 @default.
• W2188796504 cites W2157664837 @default.
• W2188796504 cites W2158757421 @default.
• W2188796504 cites W2162628305 @default.
• W2188796504 cites W2322095705 @default.
• W2188796504 cites W2322800113 @default.
• W2188796504 cites W329548293 @default.
• W2188796504 cites W67268382 @default.
• W2188796504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15274361" @default.
• W2188796504 hasPublicationYear "2004" @default.
• W2188796504 type Work @default.
• W2188796504 sameAs 2188796504 @default.
• W2188796504 citedByCount "8" @default.
• W2188796504 countsByYear W21887965042012 @default.
• W2188796504 countsByYear W21887965042016 @default.
• W2188796504 countsByYear W21887965042019 @default.
• W2188796504 countsByYear W21887965042022 @default.
• W2188796504 crossrefType "journal-article" @default.
• W2188796504 hasAuthorship W2188796504A5007028954 @default.
• W2188796504 hasAuthorship W2188796504A5012080747 @default.
• W2188796504 hasAuthorship W2188796504A5040336064 @default.
• W2188796504 hasAuthorship W2188796504A5057056068 @default.
• W2188796504 hasAuthorship W2188796504A5059536847 @default.
• W2188796504 hasAuthorship W2188796504A5061387783 @default.
• W2188796504 hasAuthorship W2188796504A5091224882 @default.
• W2188796504 hasConcept C134651460 @default.
• W2188796504 hasConcept C181199279 @default.
• W2188796504 hasConcept C190283241 @default.
• W2188796504 hasConcept C2779982574 @default.
• W2188796504 hasConcept C31573885 @default.
• W2188796504 hasConcept C502942594 @default.
• W2188796504 hasConcept C54355233 @default.
• W2188796504 hasConcept C55493867 @default.
• W2188796504 hasConcept C66008609 @default.
• W2188796504 hasConcept C81885089 @default.
• W2188796504 hasConcept C86803240 @default.
• W2188796504 hasConcept C95444343 @default.
• W2188796504 hasConcept C98274493 @default.
• W2188796504 hasConcept C98424977 @default.
• W2188796504 hasConceptScore W2188796504C134651460 @default.
• W2188796504 hasConceptScore W2188796504C181199279 @default.
• W2188796504 hasConceptScore W2188796504C190283241 @default.
• W2188796504 hasConceptScore W2188796504C2779982574 @default.
• W2188796504 hasConceptScore W2188796504C31573885 @default.
• W2188796504 hasConceptScore W2188796504C502942594 @default.
• W2188796504 hasConceptScore W2188796504C54355233 @default.
• W2188796504 hasConceptScore W2188796504C55493867 @default.
• W2188796504 hasConceptScore W2188796504C66008609 @default.
• W2188796504 hasConceptScore W2188796504C81885089 @default.
• W2188796504 hasConceptScore W2188796504C86803240 @default.
• W2188796504 hasConceptScore W2188796504C95444343 @default.
• W2188796504 hasConceptScore W2188796504C98274493 @default.
• W2188796504 hasConceptScore W2188796504C98424977 @default.
• W2188796504 hasIssue "3a" @default.
• W2188796504 hasLocation W21887965041 @default.
• W2188796504 hasOpenAccess W2188796504 @default.
• W2188796504 hasPrimaryLocation W21887965041 @default.
• W2188796504 hasRelatedWork W1559603064 @default.
• W2188796504 hasRelatedWork W1992817357 @default.
• W2188796504 hasRelatedWork W2049818544 @default.
• W2188796504 hasRelatedWork W2053443870 @default.
• W2188796504 hasRelatedWork W2068237245 @default.
• W2188796504 hasRelatedWork W2071124826 @default.
• W2188796504 hasRelatedWork W2093789049 @default.
• W2188796504 hasRelatedWork W2108527141 @default.
• W2188796504 hasRelatedWork W2112106048 @default.

• next