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- W2188809426 abstract "SUMMARY Sixty twopatients with aclinical suspicion ofbiliary dyskinesia wereinvestigated with endoscopic manometryofthesphincter ofOddibefore andafter intravenous injection of cholecystokinin orceruletide. In52patients injection was followed bydecreased pressureinthe sphincter ofOddi; 43ofthese hadnormalprestimulatory values (group I), while thevalues were raised intheother ninepatients (group II). A paradoxical responsetointravenous injection was observed in10women (group III): increased baseline sphincteric pressureoccurred ineight and increase intheamplitude ofphasic contractions infourpatients. Theprestimulatory sphincteric pressurewas raised infive andnormal intheremaining patients. Eight patients were treated with papillotomy (seven) orballoon dilatation ofthesphincter (one). Theyexperienced relief ofpain during afollow up period of11-16 months. Intravenous injection ofcholecystokinin orceruletide may disclose a special typeofbiliary dyskinesia even inpatients withnormalprestimulatory manometric findings. Hormoneinjection increases thediagnostic yield ofendoscopic manometry inpatients suspected ofbiliary dyskinesia. A paradoxical increase inthebasalsphincter of Oddipressure after injection ofcholecystokinin has recently beenobserved infive patients investigated onthesuspicion ofbiliary dyskinesia.' Thismay represent a new typeofbiliary dyskinesia as normally inman,cholecystokinin reduces orabolishes thesphincter ofOddiphasic contractions and causes amodest, butsignificant decrease inbasal sphincter ofOddipressure.2 Likewise ceruletide a synthetic analogue ofcaerulein elicits a powerful relaxing effect on sphincter ofOddipressure activity.34 We carried outendoscopic manometry ofsphincterofOddibefore andafter injection ofcholecystokininorceruletide in62patients withclinical suspicion ofbiliary dyskinesia. Tenofthepatients Addrcss torcorrespondence: PctcrRolnNiDl). )ion ot((astrocilcrolog Depirrtmciit ot'Nf cicincOrchroMcedicil (enterHosplitl. S-701 SiOrebro. Svvedcn. RecciedtoruLhliIuation 2April.9Sh showedaparadoxicalincreaseinthesphincterof Oddipressureafterhormoneinjection;eightwere submittedtopapillotomyorballoondilatationof thesphincterofOddi.Thusinthispaperwenotonly extendthepreviousobservations,'butalsoreport ourresultsoftreatmentinthisnewtypeofbiliary dyskinesia." @default.
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- W2188809426 date "1986-01-01" @default.
- W2188809426 modified "2023-09-26" @default.
- W2188809426 title "Paradoxical responseofsphincter ofOddito intravenous inj ection ofcholecystokinin orceruletide. Manometric findings andresults oftreatment in biliary dyskinesia" @default.
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