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- W2188839052 abstract "The aim of this study was to prepare fast disintegrating combination tablets of Omeprazole and Domperidone by using pertinent disintegrant. The tablets were prepared using mannitol as diluent and sodium saccharin as sweetening agent along with three different levels of disintegrant. The superdisintegrant used in this study were Kollidon CL, Ac-Di-Sol and SSG. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study. Using the same excipients, the tablets were prepared by direct compression and were evaluated in the similar way. Drug content was estimated by using HPLC method and also assay of sample was compared with standard drugs (Omeprazole and Domperidone). Omeprazole and Domperidone were well resolved and the retention times were around 9.01 and 6.2 respectively. From the results obtained, it can be concluded that the tablet formulation prepared with 4.76% Ac-Di-Sol (internally cross linked form of sodium carboxymethylcellulose) ie. 10 mg showed Disintegration time of 15 seconds in vitro. Also the hardness, friability, dissolution rate and assay of prepared tablets (batch F7) were found to be acceptable according to standard limits." @default.
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- W2188839052 date "2009-01-01" @default.
- W2188839052 modified "2023-09-27" @default.
- W2188839052 title "FAST DISINTEGRATING COMBINATION TABLETS OF OMEPRAZOLE AND DOMPERIDONE" @default.
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