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- W2188915514 abstract "In this study, the protective effect of melatonin on the radiation-damaged skin was investigated and effectiveness of the protective effect of melatonin was compared with amifostine. Fort this purpose, 40 female Sparague Dawley rats were used. Animals were divided into 5 groups. Control group (C), radiation group (R), and 2 experimental groups (radiation + melatonin 25 mg/kg (R+M) and radiation + amifostin 200 mg/kg (R+WR). A single dose of 20 gy gamma radiation were exposed to the left legs of the rat groups of R, R+M,and R+WR. At the end of a four-week of experiment period, the skin on the left femur of each rat was dissected and routine histological procedures were applied. Nikon Eclipse 400 research microscopy was used for histological observations. All histological structures of the skin were found to be normal in the control group. However, we observed that reduction in thickness of the epidermis and the dermal papillae have disappeared, sweat glands, sebaceous glands and hair follicles atrophy was observed in radiation groups. Our findings showed that R+M group, the thickness of the epidermis, collagen synthesis, R and R+WR group was better with histological structure. As a result, the histological abnormalities of radiation is shaped to protect in the skin, it has been found that melatonin has a significant effect compared to Amifostine (WR2721). Experimental article (J Int Dent Med Res 2014; 7: (3), pp. 73-77)" @default.
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- W2188915514 date "2014-01-01" @default.
- W2188915514 modified "2023-09-25" @default.
- W2188915514 title "RADIO-PROTECTIVE EFFECTS OF MELATONIN ON THE SKIN HISTOLOGY IN THE RAT" @default.
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