FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188959897> ?p ?o ?g. }

• W2188959897 endingPage "G796" @default.
• W2188959897 startingPage "G789" @default.
• W2188959897 abstract "We examined the role of the canalicular multispecific organic anion transporter (cMOAT) in the biliary excretion of reduced folate derivatives in vivo and in vitro using normal [Sprague-Dawley rats (SDR)] and mutant [Eisai hyperbilirubinemic rats (EHBR)] rats whose cMOAT is hereditarily deficient. In vivo, the biliary excretion of endogenous tetrahydrofolate (H 4 PteGlu), 5-methyltetrahydrofolate (5-CH 3 -H 4 PteGlu), and 5,10-methylenetetrahydrofolate (5,10-CH 2 -H 4 PteGlu) in EHBR was reduced to 8.2%, 1.9%, and 5.5% of those in SDR, respectively, whereas that of 10-formyltetrahydrofolate (10-HCO-H 4 PteGlu) was detected only in SDR and not in EHBR. Bile drainage caused reduction of endogenous plasma folate concentrations in SDR but not in EHBR. In vitro, significant ATP-dependent uptake of 3 H-labeled 5-CH 3 -H 4 PteGlu into canalicular membrane vesicles was observed only in SDR. This ATP-dependent uptake was saturable with a Michaelis constant ( K m ) value of 126 μM, which was comparable with its inhibitor constant ( K i ) value of 121 μM for the ATP-dependent uptake of a typical cMOAT substrate, 2,4-dinitrophenyl- S-glutathione (DNP-SG). Vice versa, DNP-SG inhibited the uptake of 5-CH 3 -H 4 PteGlu with a K i of 35 μM, which was similar to its K m value. In addition, H 4 PteGlu and 5,10-CH 2 -H 4 PteGlu also inhibited the ATP-dependent uptake of DNP-SG. These results indicate that 5-CH 3 -H 4 PteGlu and other derivatives are transported via cMOAT. Therefore, reduced folate derivatives are the first endogenous substrates for cMOAT that do not contain glutathione, glucuronide, or sulfate moieties." @default.
• W2188959897 created "2016-06-24" @default.
• W2188959897 creator A5027984186 @default.
• W2188959897 creator A5033206394 @default.
• W2188959897 creator A5037163338 @default.
• W2188959897 creator A5047497135 @default.
• W2188959897 creator A5061014418 @default.
• W2188959897 creator A5068200348 @default.
• W2188959897 date "1998-10-01" @default.
• W2188959897 modified "2023-10-18" @default.
• W2188959897 title "Reduced folate derivatives are endogenous substrates for cMOAT in rats" @default.
• W2188959897 cites W102035533 @default.
• W2188959897 cites W1502459074 @default.
• W2188959897 cites W1553996335 @default.
• W2188959897 cites W1557510459 @default.
• W2188959897 cites W1575380659 @default.
• W2188959897 cites W1646404713 @default.
• W2188959897 cites W1788126413 @default.
• W2188959897 cites W1974338599 @default.
• W2188959897 cites W1981885073 @default.
• W2188959897 cites W1993874046 @default.
• W2188959897 cites W1997929265 @default.
• W2188959897 cites W2005109202 @default.
• W2188959897 cites W2008749969 @default.
• W2188959897 cites W2020016102 @default.
• W2188959897 cites W2033230369 @default.
• W2188959897 cites W2053484522 @default.
• W2188959897 cites W2073326152 @default.
• W2188959897 cites W2078693483 @default.
• W2188959897 cites W2080346056 @default.
• W2188959897 cites W2087526401 @default.
• W2188959897 cites W2120825516 @default.
• W2188959897 cites W2125876729 @default.
• W2188959897 cites W2174979179 @default.
• W2188959897 cites W349978335 @default.
• W2188959897 cites W4235232174 @default.
• W2188959897 cites W301147989 @default.
• W2188959897 doi "https://doi.org/10.1152/ajpgi.1998.275.4.g789" @default.
• W2188959897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9756510" @default.
• W2188959897 hasPublicationYear "1998" @default.
• W2188959897 type Work @default.
• W2188959897 sameAs 2188959897 @default.
• W2188959897 citedByCount "15" @default.
• W2188959897 countsByYear W21889598972014 @default.
• W2188959897 countsByYear W21889598972016 @default.
• W2188959897 countsByYear W21889598972017 @default.
• W2188959897 countsByYear W21889598972019 @default.
• W2188959897 crossrefType "journal-article" @default.
• W2188959897 hasAuthorship W2188959897A5027984186 @default.
• W2188959897 hasAuthorship W2188959897A5033206394 @default.
• W2188959897 hasAuthorship W2188959897A5037163338 @default.
• W2188959897 hasAuthorship W2188959897A5047497135 @default.
• W2188959897 hasAuthorship W2188959897A5061014418 @default.
• W2188959897 hasAuthorship W2188959897A5068200348 @default.
• W2188959897 hasConcept C10146269 @default.
• W2188959897 hasConcept C12554922 @default.
• W2188959897 hasConcept C150903083 @default.
• W2188959897 hasConcept C16613235 @default.
• W2188959897 hasConcept C181199279 @default.
• W2188959897 hasConcept C185592680 @default.
• W2188959897 hasConcept C18903297 @default.
• W2188959897 hasConcept C202751555 @default.
• W2188959897 hasConcept C207001950 @default.
• W2188959897 hasConcept C2777289219 @default.
• W2188959897 hasConcept C538909803 @default.
• W2188959897 hasConcept C55493867 @default.
• W2188959897 hasConcept C71240020 @default.
• W2188959897 hasConcept C86803240 @default.
• W2188959897 hasConceptScore W2188959897C10146269 @default.
• W2188959897 hasConceptScore W2188959897C12554922 @default.
• W2188959897 hasConceptScore W2188959897C150903083 @default.
• W2188959897 hasConceptScore W2188959897C16613235 @default.
• W2188959897 hasConceptScore W2188959897C181199279 @default.
• W2188959897 hasConceptScore W2188959897C185592680 @default.
• W2188959897 hasConceptScore W2188959897C18903297 @default.
• W2188959897 hasConceptScore W2188959897C202751555 @default.
• W2188959897 hasConceptScore W2188959897C207001950 @default.
• W2188959897 hasConceptScore W2188959897C2777289219 @default.
• W2188959897 hasConceptScore W2188959897C538909803 @default.
• W2188959897 hasConceptScore W2188959897C55493867 @default.
• W2188959897 hasConceptScore W2188959897C71240020 @default.
• W2188959897 hasConceptScore W2188959897C86803240 @default.
• W2188959897 hasIssue "4" @default.
• W2188959897 hasLocation W21889598971 @default.
• W2188959897 hasLocation W21889598972 @default.
• W2188959897 hasOpenAccess W2188959897 @default.
• W2188959897 hasPrimaryLocation W21889598971 @default.
• W2188959897 hasRelatedWork W2002291167 @default.
• W2188959897 hasRelatedWork W2021310947 @default.
• W2188959897 hasRelatedWork W2037071640 @default.
• W2188959897 hasRelatedWork W2044079254 @default.
• W2188959897 hasRelatedWork W2055882851 @default.
• W2188959897 hasRelatedWork W2067372037 @default.
• W2188959897 hasRelatedWork W2391782128 @default.
• W2188959897 hasRelatedWork W2622510373 @default.
• W2188959897 hasRelatedWork W2974120687 @default.
• W2188959897 hasRelatedWork W752283992 @default.
• W2188959897 hasVolume "275" @default.

• next