Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188976421> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2188976421 endingPage "91" @default.
- W2188976421 startingPage "587" @default.
- W2188976421 abstract "We studied chromosomal alterations in the peripheral blood lymphocytes of 10 individuals with colorectal polyps and 10 asymptomatic first-degree relatives of patients with colon cancer or colorectal polyps. The analysis was performed on T-lymphocytes using short term blood cultures and on B-lymphocytes by establishing lymphoblastoid cell lines by Epstein-Barr virus transformation. Chromosomal changes were not common in T- and B-lymphocytes. Chromosomes 1 and 5 were most frequently involved in numerical or structural changes in the patients with polyps as well as in the asymptomatic relatives. These alterations were observed in either the T-lymphocytes or the B-lymphocytes but rarely in both, thus accentuating the importance of studying both the cultures concurrently. Chromosome 5, which is known to play an important role in the development of adenomatous polyps, was found to be involved in 6 (60%) of 10 patients with polyps and 4 (40%) of 10 asymptomatic relatives. These findings show that lymphocytic chromosomal analysis can aid in identifying individuals who are genetically susceptible and are at a higher risk of developing colorectal cancer. Because lymphocytic chromosomal analysis is relatively simple and inexpensive, we expect that it will be very useful in screening asymptomatic individuals who are at a higher risk due to inherited or environmental factors." @default.
- W2188976421 created "2016-06-24" @default.
- W2188976421 creator A5000815021 @default.
- W2188976421 creator A5016445646 @default.
- W2188976421 creator A5040639612 @default.
- W2188976421 creator A5055923908 @default.
- W2188976421 creator A5060815247 @default.
- W2188976421 creator A5079598806 @default.
- W2188976421 date "1993-11-01" @default.
- W2188976421 modified "2023-09-25" @default.
- W2188976421 title "Nonrandom chromosomal abnormalities in lymphocyte cultures of individuals with colorectal polyps and of asymptomatic relatives of patients with colorectal cancer or polyps." @default.
- W2188976421 cites W1540133525 @default.
- W2188976421 cites W1969577034 @default.
- W2188976421 cites W1994749088 @default.
- W2188976421 cites W2006874765 @default.
- W2188976421 cites W2016244564 @default.
- W2188976421 cites W2016760717 @default.
- W2188976421 cites W2058403714 @default.
- W2188976421 cites W2070168194 @default.
- W2188976421 cites W2092691551 @default.
- W2188976421 cites W2107623740 @default.
- W2188976421 cites W2131660553 @default.
- W2188976421 cites W2313948947 @default.
- W2188976421 cites W2417090228 @default.
- W2188976421 cites W2470047823 @default.
- W2188976421 cites W2470930857 @default.
- W2188976421 cites W2410725027 @default.
- W2188976421 cites W601331116 @default.
- W2188976421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8268778" @default.
- W2188976421 hasPublicationYear "1993" @default.
- W2188976421 type Work @default.
- W2188976421 sameAs 2188976421 @default.
- W2188976421 citedByCount "8" @default.
- W2188976421 countsByYear W21889764212013 @default.
- W2188976421 crossrefType "journal-article" @default.
- W2188976421 hasAuthorship W2188976421A5000815021 @default.
- W2188976421 hasAuthorship W2188976421A5016445646 @default.
- W2188976421 hasAuthorship W2188976421A5040639612 @default.
- W2188976421 hasAuthorship W2188976421A5055923908 @default.
- W2188976421 hasAuthorship W2188976421A5060815247 @default.
- W2188976421 hasAuthorship W2188976421A5079598806 @default.
- W2188976421 hasConcept C121608353 @default.
- W2188976421 hasConcept C126322002 @default.
- W2188976421 hasConcept C203014093 @default.
- W2188976421 hasConcept C2777761686 @default.
- W2188976421 hasConcept C2777910003 @default.
- W2188976421 hasConcept C2778435480 @default.
- W2188976421 hasConcept C2910480691 @default.
- W2188976421 hasConcept C526805850 @default.
- W2188976421 hasConcept C71924100 @default.
- W2188976421 hasConcept C86803240 @default.
- W2188976421 hasConcept C90924648 @default.
- W2188976421 hasConceptScore W2188976421C121608353 @default.
- W2188976421 hasConceptScore W2188976421C126322002 @default.
- W2188976421 hasConceptScore W2188976421C203014093 @default.
- W2188976421 hasConceptScore W2188976421C2777761686 @default.
- W2188976421 hasConceptScore W2188976421C2777910003 @default.
- W2188976421 hasConceptScore W2188976421C2778435480 @default.
- W2188976421 hasConceptScore W2188976421C2910480691 @default.
- W2188976421 hasConceptScore W2188976421C526805850 @default.
- W2188976421 hasConceptScore W2188976421C71924100 @default.
- W2188976421 hasConceptScore W2188976421C86803240 @default.
- W2188976421 hasConceptScore W2188976421C90924648 @default.
- W2188976421 hasIssue "6" @default.
- W2188976421 hasLocation W21889764211 @default.
- W2188976421 hasOpenAccess W2188976421 @default.
- W2188976421 hasPrimaryLocation W21889764211 @default.
- W2188976421 hasRelatedWork W1768358394 @default.
- W2188976421 hasRelatedWork W1998412152 @default.
- W2188976421 hasRelatedWork W2000538739 @default.
- W2188976421 hasRelatedWork W2075696535 @default.
- W2188976421 hasRelatedWork W2135973207 @default.
- W2188976421 hasRelatedWork W2188976421 @default.
- W2188976421 hasRelatedWork W2371295265 @default.
- W2188976421 hasRelatedWork W2411579049 @default.
- W2188976421 hasRelatedWork W2741589180 @default.
- W2188976421 hasRelatedWork W4210916850 @default.
- W2188976421 hasVolume "2" @default.
- W2188976421 isParatext "false" @default.
- W2188976421 isRetracted "false" @default.
- W2188976421 magId "2188976421" @default.
- W2188976421 workType "article" @default.