FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188997002> ?p ?o ?g. }

• W2188997002 endingPage "80" @default.
• W2188997002 startingPage "2474" @default.
• W2188997002 abstract "Interferon-alpha (IFN-α), an active cytokine, plays an important role in antiviral host responses, including protection against hepatitis B virus (HBV) infection. This study was designed to investigate the correlation between intrahepatic IFN-α expression levels and disease severity using liver biopsy specimens from HBV-infected patients with different outcomes.Immunohistochemistry (IHC) was performed to detect intrahepatic IFN-α expression in liver biopsy specimens obtained from 69 HBV-infected patients with different outcomes (including 23 cases with chronic hepatitis B [CHB], 18 cases with severe hepatitis B [SHB], and 28 cases with liver cirrhosis [LC]). In situ hybridization (ISH) was carried out to measure the levels of HBV DNA in liver samples. In addition, the liver specimens of 33 healthy liver transplant donors without detectable liver diseases comprised a normal control (NC) group.The intrahepatic expression levels of IFN-α were higher in the HBV-infected patients than the NC group (p = 0.001). Intrahepatic IFN-α expression was also significantly higher in the SHB and CHB groups compared to the NC group (p = 0.001 and p = 0.001, respectively), while the intrahepatic HBV DNA levels of the SHB patients were higher than those of LC patients (p = 0.013). Furthermore, intrahepatic IFN-α expression was positively correlated with serum alanine aminotransferase (ALT) levels in CHB patients; no significant correlations were discovered between intrahepatic IFN-α expression and intrahepatic HBV DNA levels in all other sub-groups.Intrahepatic IFN-α expression may correlate with liver inflammation after hepatitis B virus infection, and IFN-α may play a vital role in the occurrence of SHB." @default.
• W2188997002 created "2016-06-24" @default.
• W2188997002 creator A5014268039 @default.
• W2188997002 creator A5019237604 @default.
• W2188997002 creator A5020147975 @default.
• W2188997002 creator A5024474385 @default.
• W2188997002 creator A5040326429 @default.
• W2188997002 creator A5052883326 @default.
• W2188997002 creator A5059405204 @default.
• W2188997002 creator A5074954194 @default.
• W2188997002 creator A5077615666 @default.
• W2188997002 date "2013-09-01" @default.
• W2188997002 modified "2023-09-23" @default.
• W2188997002 title "Intrahepatic IFN-alpha expression in liver specimens from HBV-infected patients with different outcomes." @default.
• W2188997002 cites W1778677407 @default.
• W2188997002 cites W1982531307 @default.
• W2188997002 cites W1997691172 @default.
• W2188997002 cites W2014246786 @default.
• W2188997002 cites W2018793162 @default.
• W2188997002 cites W2024702457 @default.
• W2188997002 cites W2040148899 @default.
• W2188997002 cites W2040653543 @default.
• W2188997002 cites W2044951291 @default.
• W2188997002 cites W2045598455 @default.
• W2188997002 cites W2045853963 @default.
• W2188997002 cites W2070529016 @default.
• W2188997002 cites W2074505491 @default.
• W2188997002 cites W2080984151 @default.
• W2188997002 cites W2083781686 @default.
• W2188997002 cites W2097500515 @default.
• W2188997002 cites W2103565638 @default.
• W2188997002 cites W2109450812 @default.
• W2188997002 cites W2111922045 @default.
• W2188997002 cites W2131835803 @default.
• W2188997002 cites W2135958098 @default.
• W2188997002 cites W2150098469 @default.
• W2188997002 cites W2152385965 @default.
• W2188997002 cites W2155772701 @default.
• W2188997002 cites W2159698564 @default.
• W2188997002 cites W2169933147 @default.
• W2188997002 cites W2181354766 @default.
• W2188997002 cites W2418708707 @default.
• W2188997002 cites W39008639 @default.
• W2188997002 cites W88511296 @default.
• W2188997002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24089226" @default.
• W2188997002 hasPublicationYear "2013" @default.
• W2188997002 type Work @default.
• W2188997002 sameAs 2188997002 @default.
• W2188997002 citedByCount "3" @default.
• W2188997002 countsByYear W21889970022017 @default.
• W2188997002 countsByYear W21889970022019 @default.
• W2188997002 countsByYear W21889970022022 @default.
• W2188997002 crossrefType "journal-article" @default.
• W2188997002 hasAuthorship W2188997002A5014268039 @default.
• W2188997002 hasAuthorship W2188997002A5019237604 @default.
• W2188997002 hasAuthorship W2188997002A5020147975 @default.
• W2188997002 hasAuthorship W2188997002A5024474385 @default.
• W2188997002 hasAuthorship W2188997002A5040326429 @default.
• W2188997002 hasAuthorship W2188997002A5052883326 @default.
• W2188997002 hasAuthorship W2188997002A5059405204 @default.
• W2188997002 hasAuthorship W2188997002A5074954194 @default.
• W2188997002 hasAuthorship W2188997002A5077615666 @default.
• W2188997002 hasConcept C126322002 @default.
• W2188997002 hasConcept C142724271 @default.
• W2188997002 hasConcept C203014093 @default.
• W2188997002 hasConcept C204232928 @default.
• W2188997002 hasConcept C2522874641 @default.
• W2188997002 hasConcept C2775934546 @default.
• W2188997002 hasConcept C2777075537 @default.
• W2188997002 hasConcept C2777214474 @default.
• W2188997002 hasConcept C2777382497 @default.
• W2188997002 hasConcept C2777766500 @default.
• W2188997002 hasConcept C2780593183 @default.
• W2188997002 hasConcept C71924100 @default.
• W2188997002 hasConcept C90924648 @default.
• W2188997002 hasConceptScore W2188997002C126322002 @default.
• W2188997002 hasConceptScore W2188997002C142724271 @default.
• W2188997002 hasConceptScore W2188997002C203014093 @default.
• W2188997002 hasConceptScore W2188997002C204232928 @default.
• W2188997002 hasConceptScore W2188997002C2522874641 @default.
• W2188997002 hasConceptScore W2188997002C2775934546 @default.
• W2188997002 hasConceptScore W2188997002C2777075537 @default.
• W2188997002 hasConceptScore W2188997002C2777214474 @default.
• W2188997002 hasConceptScore W2188997002C2777382497 @default.
• W2188997002 hasConceptScore W2188997002C2777766500 @default.
• W2188997002 hasConceptScore W2188997002C2780593183 @default.
• W2188997002 hasConceptScore W2188997002C71924100 @default.
• W2188997002 hasConceptScore W2188997002C90924648 @default.
• W2188997002 hasIssue "18" @default.
• W2188997002 hasLocation W21889970021 @default.
• W2188997002 hasOpenAccess W2188997002 @default.
• W2188997002 hasPrimaryLocation W21889970021 @default.
• W2188997002 hasRelatedWork W1988831715 @default.
• W2188997002 hasRelatedWork W1997802995 @default.
• W2188997002 hasRelatedWork W1998368369 @default.
• W2188997002 hasRelatedWork W2094516312 @default.
• W2188997002 hasRelatedWork W2133277629 @default.
• W2188997002 hasRelatedWork W2348771621 @default.

• next