FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189002967> ?p ?o ?g. }

• W2189002967 abstract "Background: A number of studies have found associations between dysbindin (DTNBP1) polymorphisms and schizophrenia. Recently we identified a DTNBP1 SNP (rs9370822) that is strongly associated with schizophrenia. Individuals diagnosed with schizophrenia were nearly three times as likely to carry the CC genotype compared to the AA genotype. Methods: To investigate the importance of this SNP in the function of DTNBP1, a number of psychiatric conditions including addictive behaviours and anxiety disorders were analysed for association with rs9370822. Results: The DTNBP1 polymorphism was significantly associated with post-traumatic stress disorder (PTSD) as well as nicotine and opiate dependence but not alcohol dependence. Individuals suffering PTSD were more than three times as likely to carry the CC genotype compared to the AA genotype. Individuals with nicotine or opiate dependence were more than twice as likely to carry the CC genotype compared to the AA genotype. Conclusions: This study provides further support for the importance of DTNBP1 in psychiatric conditions and suggests that there is a common underlying molecular defect involving DTNBP1 that contributes to the development of several anxiety and addictive disorders that are generally recognised as separate clinical conditions. These disorders may actually be different expressions of a single metabolic pathway perturbation. As our participant numbers are limited our observations should be viewed with caution until they are independently replicated." @default.
• W2189002967 created "2016-06-24" @default.
• W2189002967 creator A5001014678 @default.
• W2189002967 creator A5007503233 @default.
• W2189002967 creator A5023515505 @default.
• W2189002967 creator A5035276230 @default.
• W2189002967 creator A5035788226 @default.
• W2189002967 creator A5045795880 @default.
• W2189002967 creator A5088655162 @default.
• W2189002967 date "2010-01-01" @default.
• W2189002967 modified "2023-09-27" @default.
• W2189002967 title "associated with multiple psychiatric disorders including schizophrenia" @default.
• W2189002967 cites W1966447861 @default.
• W2189002967 cites W1975599306 @default.
• W2189002967 cites W1983543998 @default.
• W2189002967 cites W1989133472 @default.
• W2189002967 cites W1990217730 @default.
• W2189002967 cites W2012410605 @default.
• W2189002967 cites W2015161406 @default.
• W2189002967 cites W2034482043 @default.
• W2189002967 cites W2035009272 @default.
• W2189002967 cites W2038051308 @default.
• W2189002967 cites W2048271986 @default.
• W2189002967 cites W2050711988 @default.
• W2189002967 cites W2057240029 @default.
• W2189002967 cites W2059990882 @default.
• W2189002967 cites W2061995731 @default.
• W2189002967 cites W2076020270 @default.
• W2189002967 cites W2076414256 @default.
• W2189002967 cites W2078715589 @default.
• W2189002967 cites W2086134998 @default.
• W2189002967 cites W2106319065 @default.
• W2189002967 cites W2109860478 @default.
• W2189002967 cites W2116386279 @default.
• W2189002967 cites W2118061336 @default.
• W2189002967 cites W2119588953 @default.
• W2189002967 cites W2129012433 @default.
• W2189002967 cites W2130555830 @default.
• W2189002967 cites W2137232739 @default.
• W2189002967 cites W2156420407 @default.
• W2189002967 cites W2159877476 @default.
• W2189002967 cites W2163214444 @default.
• W2189002967 cites W2163876269 @default.
• W2189002967 cites W2169922198 @default.
• W2189002967 hasPublicationYear "2010" @default.
• W2189002967 type Work @default.
• W2189002967 sameAs 2189002967 @default.
• W2189002967 citedByCount "0" @default.
• W2189002967 crossrefType "journal-article" @default.
• W2189002967 hasAuthorship W2189002967A5001014678 @default.
• W2189002967 hasAuthorship W2189002967A5007503233 @default.
• W2189002967 hasAuthorship W2189002967A5023515505 @default.
• W2189002967 hasAuthorship W2189002967A5035276230 @default.
• W2189002967 hasAuthorship W2189002967A5035788226 @default.
• W2189002967 hasAuthorship W2189002967A5045795880 @default.
• W2189002967 hasAuthorship W2189002967A5088655162 @default.
• W2189002967 hasConcept C104317684 @default.
• W2189002967 hasConcept C118552586 @default.
• W2189002967 hasConcept C126322002 @default.
• W2189002967 hasConcept C135763542 @default.
• W2189002967 hasConcept C139275648 @default.
• W2189002967 hasConcept C153209595 @default.
• W2189002967 hasConcept C15744967 @default.
• W2189002967 hasConcept C170493617 @default.
• W2189002967 hasConcept C2776412080 @default.
• W2189002967 hasConcept C2778140631 @default.
• W2189002967 hasConcept C2779547902 @default.
• W2189002967 hasConcept C48856860 @default.
• W2189002967 hasConcept C54355233 @default.
• W2189002967 hasConcept C558461103 @default.
• W2189002967 hasConcept C70410870 @default.
• W2189002967 hasConcept C71924100 @default.
• W2189002967 hasConcept C86803240 @default.
• W2189002967 hasConceptScore W2189002967C104317684 @default.
• W2189002967 hasConceptScore W2189002967C118552586 @default.
• W2189002967 hasConceptScore W2189002967C126322002 @default.
• W2189002967 hasConceptScore W2189002967C135763542 @default.
• W2189002967 hasConceptScore W2189002967C139275648 @default.
• W2189002967 hasConceptScore W2189002967C153209595 @default.
• W2189002967 hasConceptScore W2189002967C15744967 @default.
• W2189002967 hasConceptScore W2189002967C170493617 @default.
• W2189002967 hasConceptScore W2189002967C2776412080 @default.
• W2189002967 hasConceptScore W2189002967C2778140631 @default.
• W2189002967 hasConceptScore W2189002967C2779547902 @default.
• W2189002967 hasConceptScore W2189002967C48856860 @default.
• W2189002967 hasConceptScore W2189002967C54355233 @default.
• W2189002967 hasConceptScore W2189002967C558461103 @default.
• W2189002967 hasConceptScore W2189002967C70410870 @default.
• W2189002967 hasConceptScore W2189002967C71924100 @default.
• W2189002967 hasConceptScore W2189002967C86803240 @default.
• W2189002967 hasLocation W21890029671 @default.
• W2189002967 hasOpenAccess W2189002967 @default.
• W2189002967 hasPrimaryLocation W21890029671 @default.
• W2189002967 hasRelatedWork W11421353 @default.
• W2189002967 hasRelatedWork W149799883 @default.
• W2189002967 hasRelatedWork W1501927574 @default.
• W2189002967 hasRelatedWork W1601896670 @default.
• W2189002967 hasRelatedWork W1993182914 @default.
• W2189002967 hasRelatedWork W204807347 @default.
• W2189002967 hasRelatedWork W2085407167 @default.

• next