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- W2189061370 abstract "The development of nearest-neighbor analy- sis led to the finding that the frequency of the dinucleotide CpG is markedly depressed in vertebrates. One explanation of this suppression is that methylation of CpG found in vertebrates represents a mutational hot spot through deamination of methylcytidine to thymidine. We have examined the role of methylated CpG as a factor in CpG suppression by comparing CpG distributions in coding regions of 121 genes from six species, three with methylated DNA and three with nonmeth- ylated DNA. Overall base composition shows that all species exhibit CpG suppression, with the methylated forms showing significantly greater suppression than nonmethylated forms. When the data are analyzed by CpG position, the mean values of the methylated forms exhibit greater suppression than nonmethylated forms at positions I-II and II-II, but there is considerable overlap of suppression scores for individual spe- cies. At position III-I, CpG suppression is marked in all methylated species, and it is reversed in all nonmethylated species. Our analysis supports the hypothesis that CpG pat- terns at positions 11-111 and 111-I in methylated forms are affected by mutation acting through deamination of methylcy- tidine to thymidine. We speculate that the excess of CpGs at position III-I in nonmethylated forms may be related to a requirement for minimal thermal stability of the DNA." @default.
- W2189061370 created "2016-06-24" @default.
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- W2189061370 date "2016-01-01" @default.
- W2189061370 modified "2023-09-27" @default.
- W2189061370 title "Analysis of CpG suppression in methylated and nonmethylated species (deamination/mCpG/dinucleotide/methylation/mutation)" @default.
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