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- W2189064098 abstract "To determine the relationship between prescribed dose-intensity of chemotherapy and survival in childhood medulloblastoma.A total of 55 trials from 1970-2009 were identified, 30 were eligible for analysis, with individual treatment regimes with 5-year (or more) outcome figures. Relationships of outcome to dose-intensity were analysed using weighted regression.Overall, 2,434 patients were identified, 1,010 were classified as 'standard'- and 671 as 'high'-risk patients, with 5-year overall survivals (OS) of 67.2% (95% Confidence Interval=60.5%-73.6%) and 47.6% (95% Confidence Interval=39.5%-55.7%), respectively. A protective effect for chemotherapy versus craniospinal radiotherapy alone (5-year OS of 58.2% versus 51.6%) was found. Individually, vincristine, cisplatin, lomustine (CCNU) and cyclophosphamide appear to confer the most beneficial effect, particularly for high-risk patients. Positive relationships between OS and dose-intensity were found, except for lomustine, with cyclophosphamide offering the greatest protection.Consideration of chemotherapy dose-intensity may further optimise treatment, particularly in the context of risk stratification." @default.
- W2189064098 created "2016-06-24" @default.
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- W2189064098 date "2012-09-01" @default.
- W2189064098 modified "2023-09-27" @default.
- W2189064098 title "Chemotherapy dose-intensity and survival for childhood medulloblastoma." @default.
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