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- W2189071502 abstract "The ionic currents through sodium channels of nodal membrane were measured under voltage clamp conditions at normal and low pH external solutions. Inhibition of the currents at low pH was described on the assumption that there are two acid groups at the sodium channel: one (inner) within the pore, the second (surface) just near external end of the pore. The protonation of the inner group is potential-dependent and causes an almost complete blockage of the channel; the protonation of the surface group is potential-independent and results in a partial decrease in channel conductance. Calculations according to this model allowed an estimatation of effective pK values for each of the groups, the electric distance from the outer to the inner group and the degree of Coulombic interaction between both groups. From reversal potential measurements, relative permeability of the sodium channels to H + ions (PJPNa) was estimated to be 274 ±156 (±S.D.)." @default.
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- W2189071502 date "1982-01-01" @default.
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- W2189071502 title "Interaction of H + Ions with Acid Groups in Normal Sodium Channels" @default.
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